Mar 11, 2005

Sleep-related brain activation does not increase the permeability of the blood-brain barrier to glucose

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Alessandro SilvaniG Zoccoli

Abstract

We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness (n=12) or REM sleep (n=7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly increased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-m...Continue Reading

  • References19
  • Citations5

References

  • References19
  • Citations5

Mentioned in this Paper

Surface Electromyography
Metabolic Process, Cellular
Cerebral Blood Flow Imaging
Blood - Brain Barrier Anatomy
Implantable Stimulation Electrodes
Sleep, Slow-Wave
Brain
Permeability
Glucose, (beta-D)-Isomer
Rats, Sprague-Dawley

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