Sleep-related breathing disorder in children with vagal nerve stimulators

Pediatric Neurology
Tauyee HsiehYemiserach Kifle

Abstract

The effects of vagal nerve stimulation on sleep-related breathing have not been well-described in children. Vagal nerve stimulation was reported to cause decreases in airflow during sleep, although most studies reported this condition to be clinically insignificant. We present a retrospective case series of nine children who underwent polysomnography after vagal nerve-stimulator placement. All children, except for one, had sleep-disordered breathing after stimulator implantation. We describe in further detail a child who manifested severe, obstructive sleep apnea postimplantation, with apneas occurring regularly and consistently with stimulator activity, resulting in an elevated apnea-hypopnea index of 37 per hour. Polysomnography was repeated with the stimulator turned off, and revealed complete resolution of the stimulator-related sleep apnea. With the vagal nerve stimulator back on, continuous positive airway pressure treatment was effective in normalizing the apnea-hypopnea index. This study demonstrates that severe and clinically significant disturbances in sleep-related breathing may occur with vagal nerve stimulators. Obstructive apneas of this severity, related to vagal nerve stimulators, were not previously described i...Continue Reading

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Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew H MilbyGordon H Baltuch
Sep 8, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Fuzhan ParhizgarRishi Raj
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Mar 20, 2020·Anesthesia Progress·Kazuaki YamagataMitsutaka Sugimura
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Jan 24, 2021·Sleep Medicine·Thomas J DyeNarong Simakajornboon
Apr 2, 2021·Annals of the American Thoracic Society·Rahul VermaAaron St-Laurent

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