Sleep-related disorders and their relationship with MRI findings in multiple sclerosis

Sleep Medicine
M FoschiLuigi Ferini-Strambi

Abstract

Sleep-related disorders have been reported to have a higher prevalence in multiple sclerosis (MS) than in the general population. They are often undervalued for the presence of more severe physical problems and the occurrence at night, without a direct observation in common clinical practice, but if not recognized and treated they can negatively affect the quality of life causing daytime drowsiness and worsening fatigue. Sleep related disorders most commonly reported in MS are as follows: insomnia, sleep-related breathing disorders (SRBD), restless legs syndrome (RLS) and periodic limb movement disorders (PLMD). Secondary narcolepsy, REM sleep behavior disorder (RBD) and propriospinal myoclonus have been also described in some case reports or series. The purpose of this review is to correlate the more common sleep disturbances in MS patients to the involvement of specific brain regions, analyzing their relationship with MRI findings. While insomnia is usually secondary to other disabling symptoms such as nocturia or pain, SRBD, RLS, narcolepsy, RBD and propriospinal myoclonus in MS patients can be the consequence of an injury of specific central nervous system (CNS) areas. Lesions in the pontine tegmentum and the dorsal medulla...Continue Reading

Citations

Jul 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alex Iranzo
Jun 27, 2019·Glia·Luisa de Vivo, Michele Bellesi
Dec 19, 2019·Journal of Clinical Medicine·Lorenzo TonettiAlessandra Lugaresi
Aug 7, 2020·Continuum : Lifelong Learning in Neurology·Sara E Benjamin
Sep 26, 2020·Frontiers in Neurology·Melinda Magyari, Per Soelberg Sorensen
Feb 5, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Sinéad ZeidanElisabeth Maillart
May 24, 2020·Annals of Physical and Rehabilitation Medicine·Antoine LéotardSebastien Baillieul
Apr 1, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle F Devine, Erik K St Louis
May 6, 2021·Annals of Clinical and Translational Neurology·James F SumowskiAndrew W Varga
May 24, 2021·The Nursing Clinics of North America·Yolanda Smith Wheeler, Karen Heaton

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