Sleep, respiratory physiology, and nocturnal asthma
The nocturnal worsening of asthma is a common feature of this disease that recently has received extensive investigation. Most recent efforts have focused on the role of circadian biorhythms that could promote a nocturnal increase in airway inflammation, leading to a subsequent increase in airflow obstruction and asthma symptoms. However, definitive studies remain lacking. As discussed in this review, there is also substantial evidence that sleep itself may play a direct role in the nocturnal worsening of asthma. Potential mechanisms for such a sleep-related effect could include the supine posture, alterations in sympathetic and parasympathetic "balance," sleep-associated reductions in lung volume, intrapulmonary pooling of blood, and sleep-associated upper airway narrowing, both with and without snoring and obstructive sleep apnea (OSA). These potential contributors to this troublesome phenomenon deserve further consideration when investigating mechanisms of nocturnal asthma.
Influence of posture and sustained loss of lung volume on pulmonary function in awake asthmatic subjects
Alterations in pulmonary diffusing capacity and pulmonary capillary blood volume with negative pressure breathing
Cyclical variation of the heart rate in sleep apnoea syndrome. Mechanisms, and usefulness of 24 h electrocardiography as a screening technique
Mechanisms of airway narrowing in acute pulmonary oedema in dogs: influence of the vagus and lung volume
Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries
The relationship between airway resistance, airway conductance and lung volume in subjects of different age and body size
Effect of changes in blood gas tensions and carotid sinus pressure on tracheal volume and total lung resistance to airflow
Gastroesophageal reflux episodes in asthmatic patients and their temporal relation with sleep architecture
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.