Sleep restriction during peripuberty unbalances sexual hormones and testicular cytokines in rats

Biology of Reproduction
Gláucia E M L SiervoGlaura S A Fernandes

Abstract

Spermatogenesis and steroidogenesis are not fully established during puberty. Especially during this period, children and adolescents may be chronically sleep deprived due to early school hours and constant exposure to artificial light and interactive activities. We have previously shown that sleep restriction (SR) during peripuberty impairs sperm motility and has consequences on epididymal development in rats. Thus, this study aimed to evaluate the effect of SR during peripuberty on sexual hormones and its impact on testicular tissue. Rats were subjected to 18 h of SR per day for 21 days or were maintained as controls (C) in the same room. The circulating luteinizing hormone levels were decreased in SR rats without changes in the follicle stimulating hormone levels. Plasma and intratesticular testosterone and corticosterone in the SR group were increased in relation to C group. These alterations impair testicular tissue, with decreased IL-1β, IL-6, and TNFα levels in the testis and diminished seminiferous epithelium height and Sertoli cell number. SR also increased testicular lipid peroxidation with no alteration in antioxidant profiles. There were no significant changes in sperm parameters, seminiferous tubule diameter, histo...Continue Reading

References

Sep 1, 1978·Journal of Reproduction and Fertility·G W RobbG J Killian
Jan 1, 1988·Annals of the New York Academy of Sciences·G FortiM Serio
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Nov 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·M RepettoS Llesuy
Dec 29, 2000·The Journal of Parasitology·F J Oliveira, R Cecchini
Feb 19, 2002·Molecular and Cellular Endocrinology·C PetersenO Söder
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Ida Norgil DamgaardNiels E Skakkebaek
Mar 1, 2003·Journal of Reproductive Immunology·Mark P Hedger, Andreas Meinhardt
May 30, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard M SharpeJane S Fisher
Feb 7, 2004·Journal of Neuroendocrinology·M Levy AndersenS Tufik
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Mar 4, 2005·Journal of Sleep Research·Monica L AndersenSergio Tufik
May 3, 2005·Behavioural Brain Research·Ricardo Borges MachadoSergio Tufik
Sep 19, 2006·Metabolism: Clinical and Experimental·Bruce S McEwen
Oct 31, 2006·Reproductive Toxicology·Glaura S A FernandesWilma G Kempinas
Dec 13, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Emel Sahin, Saadet Gümüşlü
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A ZagerS Tufik
Feb 5, 2008·Animal Reproduction Science·Larry JohnsonDickson D Varner
Mar 15, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fei LongXian-Qiao Jin
Feb 12, 2009·Nature Reviews. Neuroscience·Luca Imeri, Mark R Opp
May 26, 2009·Behavioural Brain Research·Tathiana A AlvarengaSergio Tufik
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Sergio TufikMarco T de Mello
Nov 11, 2009·Journal of Natural Products·Daniel A ValérioWaldiceu A Verri
Sep 6, 2011·Brain Research·Monica L AndersenSergio Tufik
Apr 26, 2012·American Journal of Reproductive Immunology : AJRI·Soren HayrabedyanNelson Fernández
Jun 16, 2012·Frontiers in Immunology·Nan LiDaishu Han
Nov 20, 2012·Journal of Ethnopharmacology·Cíntia Delai da Silva HorinouchiMichel Fleith Otuki
Jun 24, 2014·Cellular & Molecular Immunology·Shutao ZhaoDaishu Han
Aug 15, 2014·Journal of Adolescence·Jasper WolfeMichelle A Short
Aug 27, 2014·Pediatrics·Judith OwensUNKNOWN Committee on Adolescence
Dec 10, 2014·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall

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Citations

Feb 11, 2020·Systems Biology in Reproductive Medicine·Wenyang ChenGuirong Zhang

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