Sleep disordered breathing (SDB) is now well recognized in children with neuromuscular diseases (NMD) and may lead to significant morbidity and increased mortality. Predisposing factors to SDB in children with NMD include reduced ventilatory responses, reduced activity of respiratory muscles during sleep and poor lung mechanics due to the underlying neuro-muscular disorder. SDB may present long before signs of respiratory failure emerge. When untreated, SDB may contribute to significant cardiovascular morbidities, neuro-cognitive deficits and premature death. One of the problems in detecting SDB in patients with NMD is the lack of correlation between lung function testing and daytime gas exchange. Polysomnography is the preferred method to evaluate for SDB in children with NMD. When the diagnosis of SDB is confirmed, treatment by non-invasive ventilation (NIV) is usually recommended. However, other modalities of mechanical ventilation do exist and may be indicated in combination with or without other supportive measures.
Breathing patterns and HbSaO2 changes during nocturnal sleep in patients with Duchenne muscular dystrophy
Peripheral chemoreceptor function in children with myelomeningocele and Arnold-Chiari malformation type 2
Use of BiPAP by nasal mask in the treatment of respiratory insufficiency in pediatric patients: preliminary investigation
Sleep and neuromuscular disease: frequency of sleep-disordered breathing in a neuromuscular disease clinic population
Sleep-disordered breathing in Duchenne muscular dystrophy: a preliminary study of the role of portable monitoring
Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea
Sleep-related breathing disorder in Duchenne muscular dystrophy: disease spectrum in the paediatric population
The effect of treatment of obstructive sleep apnea on quality of life in children with cerebral palsy
Effect of non-invasive ventilation on respiratory muscle loading and endurance in patients with Duchenne muscular dystrophy
The use of mechanical ventilation is appropriate in children with genetically proven spinal muscular atrophy type 1: the motion for
Increased prevalence of obstructive sleep apnoea in patients with Charcot-Marie-Tooth disease: a case control study
Can daytime measures of lung function predict respiratory failure in children with neuromuscular disease?
Neuromuscular disease and respiratory physiology in children: putting lung function into perspective
Screening for sleep-disordered breathing with Pediatric Sleep Questionnaire in children with underlying conditions
Are respiratory muscle testing helpful to prompt sleep studies in children with neuromuscular disease?
Slow oscillation density and amplitude decrease across development in pediatric Duchenne and Becker muscular dystrophy.
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