Sleep spindle activity in children with obstructive sleep apnea as a marker of neurocognitive performance: A pilot study

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Pablo E BrockmannOliviero Bruni

Abstract

To assess spindle activity as possible markers for neurocognitive consequences in children with mild obstructive sleep apnea. Children aged 6-11 years diagnosed with mild OSA (i.e., an apnea hypopnea index <5.0) were recruited and compared with age and gender-matched healthy controls. Polysomnographic recordings were analyzed for sleep microstructure and spindle activity. All children completed also an intelligence test battery (i.e., the Wechsler intelligence test for children, 4th version). Nineteen children with OSA (13 boys, mean age 7.1 ± 1.4 y), and 14 controls (7 boys, mean age 8.1 ± 1.9 y) were included. Mean IQ was 110 ± 12 for the complete sample, in children with OSA 111 ± 13, and in controls 108 ± 12 (p = 0.602). Controls showed a higher spindle index in N2 stage than children with OSA: 143.0 ± 42.5 vs 89.5 ± 56.9, respectively (p = 0.003). Spindle index in NREM was strongly and significantly correlated with Verbal Comprehension Index (VCI), Working Memory Index (WMI), Processing Speed Index (PSI), and total IQ in children with OSA. Children with mild OSA demonstrate a different pattern of sleep spindle activity that seems to be linked with neurocognitive performance, especially concerning memory. Sleep spindle acti...Continue Reading

Citations

Feb 6, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Pablo E BrockmannOliviero Bruni
Aug 1, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Arvind ChandrakantanAdam C Adler
Feb 3, 2021·Pediatric Pulmonology·Lourdes M DelRossoRaffaele Ferri
Dec 5, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Saramia SulkamoSari-Leena Himanen
Feb 22, 2021·Sleep Medicine Reviews·Simone S M VisserJeroen Dudink
Mar 16, 2021·Frontiers in Neurology·Hiwa MohammadiSerge Brand
Apr 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lourdes M DelRossoRaffaele Ferri
Sep 21, 2019·Journal of Affective Disorders·Jessica M MeersCandice A Alfano
Nov 23, 2021·Frontiers in Neuroscience·Gonzalo C Gutiérrez-TobalRoberto Hornero

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