Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis.

Psychophysiology
Albert C YangRobert Joseph Thomas

Abstract

Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment. We evaluated the utility of electrocardiogram (ECG)-based cardiopulmonary coupling analysis to quantify physiologic sleep stability in patients with major depression. Relative to controls, unmedicated depressed patients had a reduction in high-frequency coupling, an index of stable sleep, an increase in low-frequency coupling, an index of unstable sleep, and an increase in very-low-frequency coupling, an index of wakefulness/REM sleep. The medicated depressed group showed a restoration of stable sleep to a level comparable with that of the control group. ECG-based cardiopulmonary coupling analysis may provide a simple, cost-efficient point-of-care method to quantify sleep quality/stability and to objectively evaluate the severity of insomnia in patients with major depression.

References

Mar 7, 1998·Archives of General Psychiatry·M E ThaseC F Reynolds
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M LiottiD Denton
Oct 24, 2001·Circulation·R M CarneyK E Freedland
May 2, 2002·Biological Psychiatry·Vikram Kumar YeraganiK Srinivasan
Jan 18, 2003·Sleep Medicine Reviews·Joëlle Adrien
Jan 18, 2003·Sleep Medicine Reviews·Mario Giovanni Terzano, Liborio Parrino
Aug 2, 2003·Biological Psychiatry·Robert M Carney, Kenneth E Freedland
Sep 2, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mario Giovanni TerzanoArianna Smerieri
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 13, 2003·Journal of Affective Disorders·Benedetto FarinaEllen Frank
Mar 16, 2004·Psychosomatics·Eitan NahshoniAbraham Weizman
Aug 6, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Martine DumontPaul Linkowski
Oct 7, 2004·The American Journal of Psychiatry·Anne GermainDaniel J Buysse
Nov 30, 2004·Lancet·Michael J Sateia, Peter D Nowell
Aug 30, 2005·Journal of Psychosomatic Research·Shelley S TworogerAnne McTiernan
Nov 5, 2005·Sleep·Robert Joseph ThomasAry L Goldberger
Oct 6, 2006·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jos F BrosschotJulian F Thayer
Oct 17, 2006·Sleep·Daniel J BuysseCharles M Morin
Feb 12, 2008·American Journal of Respiratory and Critical Care Medicine·Andreas von LeupoldtChristian Büchel
Nov 26, 2008·Biological Psychiatry·Philip van EijndhovenIndira Tendolkar

❮ Previous
Next ❯

Citations

Jan 29, 2013·Sleep & Breathing = Schlaf & Atmung·John HarringtonTeofilo L Lee-Chiong
Nov 19, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Preetam J SchrammUma Rao
Oct 26, 2012·ISRN Neurology·Jessica M KellyMatt T Bianchi
May 28, 2011·Sleep Medicine Reviews·Liborio ParrinoMario G Terzano
Jun 29, 2012·The Laryngoscope·Seung Hoon LeeChang-Ho Yun
Dec 3, 2011·The Journal of Rheumatology·Robert Joseph Thomas
Jun 22, 2019·Sleep & Breathing = Schlaf & Atmung·Yan MaChung-Kang Peng
Oct 1, 2011·Journal of Sleep Research·Matt T BianchiRobert J Thomas
Sep 28, 2017·Journal of Medical Systems·Jong-Uk ParkKyoung-Joung Lee
Jan 21, 2021·Annals of the American Thoracic Society·Haitham S Al AshryUNKNOWN APPLES Investigators
Aug 17, 2021·Computers in Biology and Medicine·Dong Yeon SonKwang Suk Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.