Sleep timing may modulate the effect of sleep loss on testosterone

Clinical Endocrinology
Sebastian M SchmidBernd Schultes

Abstract

Sleep loss has been shown to reduce secretory activity of the pituitary-gonadal axis in men, but the determinants of this effect are unknown. To discriminate the effects of sleep duration and sleep timing on serum concentrations of luteinizing hormone (LH), testosterone (T) and prolactin (PRL). Fifteen young, healthy men (27·1 ± 1·3 years; BMI, 22·9 ± 0·3 kg/m(2) ) were examined in a condition of sleep time restriction to 4 h (bedtime, 02:45 -07:00 h) for two consecutive nights and in a control condition of 8 h regular sleep (bedtime, 22:45-07:00 h). After the second night, serum concentrations of LH, T and PRL were monitored over a 15-h period. In addition, these hormones were measured in serum samples obtained in a further experiment in eight healthy men (24·5 ± 1·1 years; BMI, 23·7 ± 0·6 kg/m(2) ) in the morning after one night of total sleep deprivation, of 4·5 h sleep (bedtime, 22:30-03:30 h), and of regular 7 h sleep (bedtime, 22:30-06:00 h). Serum LH, T and PRL concentrations showed characteristic diurnal variations across the 15-h period without any differences between the 4- and 8-h sleep conditions. However, total sleep deprivation and 4·5 h of sleep restricted to the first night-half markedly decreased morning T and ...Continue Reading

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Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jessica A Mong, Danielle M Cusmano
May 2, 2015·International Journal of Cardiology·Fabien SauvetMounir Chennaoui
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