Sleep-wake control and the thalamus

Current Opinion in Neurobiology
Thomas C GentAntoine Adamantidis

Abstract

Sleep is an essential component of animal behavior, controlled by both circadian and homeostatic processes. Typical brain oscillations for sleep and wake states are distinctive and reflect recurrent activity amongst neural circuits spanning localized to global brain regions. Since the original discovery of hypothalamic centers controlling both sleep and wakefulness, current views now implicate networks of neuronal and non-neuronal cells distributed brain-wide. Yet the mechanisms of sleep-wake control remain unclear. In light of recent studies, here we review experimental evidence from lesional, correlational, pharmacological and genetics studies, which support a role for the thalamus in several aspects of sleep-wake states. How these thalamo-cortical network mechanisms contribute to other executive functions such as memory consolidation and cognition, remains an open question with direct implications for neuro-psychiatric diseases and stands as a future challenge for basic science and healthcare research.

Citations

Mar 18, 2019·Neuroscience Bulletin·Yu-Feng ShaoYi-Ping Hou
Feb 6, 2020·Molecular Psychiatry·Wei ChengJianfeng Feng
Dec 19, 2018·Nature Neuroscience·Xiao YuWilliam Wisden
Aug 15, 2020·Frontiers in Neurology·Cenglin XuZhong Chen
Dec 9, 2020·BMC Neurology·Peter Nørregaard HansenChristoph P Beier
Nov 20, 2020·Lancet Neurology·Amaia Muñoz-LopetegiJoan Santamaria
Feb 21, 2021·Sleep·Christopher E J DopplerMichael Sommerauer
May 19, 2021·Cerebral Cortex·Isabel Pérez-SantosCarmen Cavada
May 25, 2021·Frontiers in Psychiatry·Farnoosh EmamianMojtaba Zarei
Jun 8, 2021·Brain Communications·Enmanuelle Pardilla-DelgadoYakeel T Quiroz
Jul 9, 2021·Nature and Science of Sleep·Chao HaoNing Ma
Jul 11, 2020·Current Opinion in Physiology·Heinrich S Gompf, Christelle Anaclet
Sep 13, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A ComanducciM Massimini

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