Sleep-Wake Neurochemistry

Sleep Medicine Clinics
Sebastian C Holst, Hans-Peter Landolt

Abstract

The regulated alternations between wakefulness and sleep states reflect complex behavioral processes, orchestrated by distinct neurochemical changes in brain parenchyma. No single neurotransmitter or neuromodulator controls the sleep-wake states in isolation. Rather, fine-tuned interactions within organized neuronal circuits regulate waking and sleep states and drive their transitions. Structural or functional dysregulation and medications interfering with these ensembles can lead to sleep-wake disorders and exert wanted or unwanted pharmacological actions on sleep-wake states. Knowledge of the neurochemical bases of sleep-wake states, which will be discussed in this article, provides the conceptual framework for understanding pharmacological effects on sleep and wake.

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Citations

Jun 25, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Ian M Colrain
Mar 19, 2019·Anesthesia and Analgesia·Max B KelzKen Solt
Feb 28, 2020·Experimental and Therapeutic Medicine·Zi-Wen ChenFu-Ping Xu
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Oct 23, 2020·Journal of Evidence-based Integrative Medicine·Noriko ShinjyoJulia Green
Nov 22, 2018·Clocks & Sleep·Susanne WeigendHans-Peter Landolt
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Jun 3, 2021·Journal of Clinical Medicine·Reetta M Sipilä, Eija A Kalso
Jul 29, 2021·Journal of Psychopharmacology·Philippe GarciaFrançois Montastruc

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