Sleep-wakefulness in alcohol preferring and non-preferring rats following binge alcohol administration.

Neuroscience
M M ThakkarP Sahota

Abstract

The alcohol-preferring (P) rat is a valid animal model of alcoholism. However, the effect of alcohol on sleep in P or alcohol non-preferring (NP) rats is unknown. Since alcohol consumption has tremendous impact on sleep, the present study compared the effects of binge alcohol administration on sleep-wakefulness in P and NP rats. Using standard surgical procedures, the P and NP rats were bilaterally implanted with sleep recording electrodes. Following post-operative recovery and habituation, pre-ethanol (baseline) sleep-wakefulness was electrographically recorded for 48 h. Subsequently, ethanol was administered beginning with a priming dose of 5 g/Kg followed by two doses of 2 g/Kg every 8 h on the first day and three doses of 3 g/Kg/8 h on the second day. On the following day (post-ethanol), undisturbed sleep-wakefulness was electrographically recorded for 24 h. Our initial results suggest that, during baseline conditions, the time spent in each of the three behavioral states: wakefulness, non-rapid eye movement (NREM) sleep and REM sleep, was comparable between P and NP rats. However, the P rats were more susceptible to changes in sleep-wakefulness following 2 days of binge ethanol treatment. As compared to NP rats, the P rats...Continue Reading

References

Jul 1, 1978·Journal of Studies on Alcohol·W B MendelsonR J Wyatt
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·L LumengT K Li
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·D L KurtzJ C Froehlich
May 20, 1998·Pharmacology, Biochemistry, and Behavior·S RouhaniS Poenaru
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·S P DrummondA DeModena
May 29, 1999·Critical Reviews in Neurobiology·W J McBride, T K Li
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·J H Foster, T J Peters
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·Z A Rodd-HenricksT K Li
Mar 17, 2000·Alcohol·C L Ehlers, C J Slawecki
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·K L NowakJ M Murphy
Mar 7, 2001·The American Journal of Psychiatry·K J BrowerJ F Greden
Jun 21, 2001·Journal of Studies on Alcohol·K J Brower, J M Hall
May 1, 2002·Alcoholism, Clinical and Experimental Research·J A ObernierF T Crews
Jan 18, 2003·Sleep Medicine Reviews·Timothy Roehrs, Thomas Roth
Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Fulton T Crews, Christopher J Braun
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Z A RoddW J McBride
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Fulton T CrewsAntonio Noronha
Jan 31, 2006·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
Jan 31, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jean H KimSian M Griffiths
Oct 23, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Fulton T Crews, Kim Nixon
Feb 27, 2010·Alcoholism, Clinical and Experimental Research·Rishi SharmaMahesh M Thakkar
Apr 9, 2010·Alcoholism, Clinical and Experimental Research·Mahesh M ThakkarPradeep Sahota

❮ Previous
Next ❯

Citations

Sep 30, 2010·Journal of Neurotrauma·Sylvia PrilloffBernhard A Sabel
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Rishi SharmaMahesh M Thakkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.