Sleeping chILD: Neuroendocrine cell hyperplasia of infancy and polysomnography

Pediatric Pulmonology
Deborah R LiptzinRobin R Deterding

Abstract

Neuroendocrine cell hyperplasia of infancy (NEHI) is a children's interstitial and diffuse lung disease of unknown etiology that presents in infancy with characteristic findings of tachypnea, retractions, crackles, and hypoxemia. At the present, the mainstay of treatment is oxygen supplementation to normalize oxygen saturations and decrease work of breathing. There are characteristic pulmonary function, radiographic, and histologic findings, but polysomnography (PSG) data has not been reported. We sought to report PSG data and implications for management and treatment of NEHI patients. A retrospective chart review was performed under a Colorado Institutional Review Board approved protocol for which consent was waived. Informatics for Integrating Biology and the Bedside was used to query the electronic medical record at Children's Hospital Colorado for patients with both a diagnosis of NEHI and a PSG. PSG was performed for clinical reasons. Routine sleep quality and respiratory parameters were recorded and analyzed. Of our 77 patients with NEHI, 14 (19%) children underwent PSG during the study period. Eight children met criteria for OSA and three met criteria for CSA. Ten patients had low oxygen saturations during a study, six h...Continue Reading

References

Mar 12, 2002·Pediatric Pulmonology·R R DeterdingC Langston
Jun 21, 2005·Pediatric Pulmonology·Robin R DeterdingClaire Langston
Sep 8, 2006·Pediatric Radiology·Alan S Brody, Eric J Crotty
Apr 3, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Y DauvilliersP Bourgin
Aug 29, 2012·Pediatrics·Carole L MarcusUNKNOWN American Academy of Pediatrics
Nov 22, 2012·Pediatric Pulmonology·Gwendolyn S KerbyRobin R Deterding
Aug 27, 2013·Neuropsychiatric Disease and Treatment·Maria EspositoMarco Carotenuto
Feb 8, 2014·Chest·Leila Kheirandish-GozalDavid Gozal
Nov 26, 2015·Current Problems in Pediatric and Adolescent Health Care·Anil Gungor, Christopher Cielo

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Citations

Feb 2, 2019·American Journal of Respiratory and Critical Care Medicine·Don HayesRobin R Deterding
Feb 29, 2020·Annals of the American Thoracic Society·Deborah R LiptzinRobin R Deterding
Feb 7, 2021·Sleep Medicine·Diane Abdel-Latif ThomassonBrigitte Fauroux

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