PMID: 999395Sep 1, 1976

Sleeping time and awaking blood concentration of hexobarbital influenced by glucose and adrenaline in rats of both sexes

Archives Internationales De Pharmacodynamie Et De Thérapie
R Wenzlik, W Klinger


Sleeping times in male and femal rats are prolonged after the simultaneous i.p. administration of adrenaline and hexobarbital sodium. The blood concentration of hexobarbital at awakening is unchanged in male rats, while in females this concentration is decreased. When adrenaline is given s.c., no change in sleeping times is observed in female and male rats, while the blood concentration of hexobarbital for the two sexes is decreased. Glucose, given p.o. or i.p., has no influence on sleeping times or on hexobarbital concentrations. The hexobarbital concentrations at awakening is higher in female than in male rats.

Related Concepts

Drug Interactions
Glucose, (beta-D)-Isomer
Sleep, Slow-Wave

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