Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats

Obesity Surgery
Leire Méndez-GiménezGema Frühbeck

Abstract

Glycerol constitutes an important metabolite for the control of lipid accumulation and glucose homeostasis. Our aim was to investigate the potential role of aquaglyceroporins, which are glycerol channels mediating glycerol efflux in adipocytes (AQP3 and AQP7) and glycerol influx (AQP9) in hepatocytes, in the improvement of adiposity and hepatic steatosis after sleeve gastrectomy in an experimental model of diet-induced obesity (DIO). Male Wistar DIO rats (n = 161) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary interventions [fed ad libitum a normal diet (ND) or a high-fat diet (HFD) or pair-fed to the amount of food eaten by sleeve-gastrectomized animals]. The tissue distribution and expression of AQPs in biopsies of epididymal (EWAT) and subcutaneous (SCWAT) white adipose tissue and liver were analyzed by real-time PCR, Western blot, and immunohistochemistry. Four weeks after surgery, DIO rats undergoing sleeve gastrectomy showed a reduction in body weight, whole-body adiposity, and hepatic steatosis. DIO was associated with a tendency towards an increase in EWAT AQP3 and SCWAT AQP7 and a decrease in hepatic AQP9. Sleeve gastrectomy downregulated AQP7 in both fat depots and upregulated AQP3 in EW...Continue Reading

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Citations

Nov 26, 2015·Frontiers in Endocrinology·Amaia RodríguezGiuseppe Calamita
Jun 9, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H Frikke-SchmidtR J Seeley
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Sep 4, 2015·American Journal of Physiology. Endocrinology and Metabolism·Amaia RodriguezGema Frühbeck
Nov 9, 2017·Scientific Reports·Hailan WuZhao He
Jun 20, 2018·International Journal of Molecular Sciences·Matteo TardelliMichael Trauner
Jul 22, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S EzquerroA Rodríguez
Mar 28, 2017·Obesity Surgery·Joana RossellJuan Antonio Baena-Fustegueras
Apr 21, 2018·Frontiers in Chemistry·Leire Méndez-GiménezAmaia Rodríguez
Apr 3, 2020·Journal of Physiology and Biochemistry·A RodríguezSara Becerril
Jun 6, 2021·Redox Biology·Mauro GalliPiotr Zabielski

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