Sleeve gastrectomy relieves steatohepatitis in high-fat-diet-induced obese rats.

Obesity Surgery
Yong Wang, Jingang Liu

Abstract

Sleeve gastrectomy is thought to decrease the appetite and body weight of morbid obesity patients in the clinic. The purpose is to investigate the effect of sleeve gastrectomy on preventing steatohepatitis in morbid obesity rats. Thirty rats were randomized into normal chow group (NC), high-fat-diet group (HD), and sleeve group (SG). Rats in the SG group received sleeve gastrectomy operation. After operation, rats in SG and HD group received a high-fat diet, while rats in the NC group received normal chow. Body weight was measured every 10 days. Thirty days later, animals were sacrificed and blood samples were collected to check total cholesterol, HDL, and triglyceride. Fresh liver sections were made and stained with Nile red and observed under a fluorescence microscope. Rats in the SG group received a moderate body weight decrease (191 +/- 16.2 g) in the first 10 days, while this did not happen in the other two groups (213 +/- 13.7 g and 243 +/- 11.9 g). At the sacrifice date, weight of rats in the SG group was still much lower than those in the HD group. Plasma triglycerol (102.3 +/- 18.6 mg/dL) and cholesterol (84.3 +/- 6.1 mg/dL) of rats in the SG group were much lower than those in the HD group (198.5 +/- 18.5 mg/dL, 133.9...Continue Reading

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Citations

Oct 24, 2012·Molecular Aspects of Medicine·Margaret A StefaterThomas H Inge
Nov 19, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Tatiana Z BrinckerhoffDaniel A DeUgarte
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W Yu
Jun 23, 2012·Obesity Facts·Lars FischerBeat Müller-Stich
Jul 22, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S EzquerroA Rodríguez

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