SlimQuick™ - associated hepatotoxicity in a woman with alpha-1 antitrypsin heterozygosity.

World Journal of Hepatology
Douglas H WeinsteinAyse L Mindikoglu

Abstract

Green tea (Camellia sinensis)-associated hepatotoxicity is reported. However, the presence of alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated drug-induced liver injury (DILI) is unknown. A previously healthy woman with alpha-1 antitrypsin MZ phenotype who took SlimQuick™, an herbal supplement containing green tea extract, developed severe hepatotoxicity requiring corticosteroid treatment. Green tea-associated hepatotoxicity is reviewed and alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated DILI is discussed. Liver biopsy demonstrated marked inflammation with necrosis suggestive of toxic injury with diffuse alpha-1 antitrypsin globule deposition on immunostaining. Corticosteroid therapy resulted in rapid clinical improvement. Alpha-1 antitrypsin MZ phenotype may increase vulnerability to herbal hepatotoxicity.

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Citations

Nov 28, 2014·Chinese Journal of Integrative Medicine·Tony Yuqi TangJanyne Afseth
Jul 8, 2015·Expert Opinion on Drug Metabolism & Toxicology·Carlemi CalitzSias Hamman
Mar 6, 2013·Expert Opinion on Drug Safety·Rolf TeschkeJohannes Schulze
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Feb 15, 2015·Archives of Toxicology·Felix Stickel, Daniel Shouval
Apr 14, 2016·International Journal of Molecular Sciences·Miren García-CortésRaul J Andrade
May 18, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elizabeth X ZhengVictor J Navarro
Jul 13, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy Christine Brown

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