Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease

The Journal of Immunology : Official Journal of the American Association of Immunologists
Roshini FernandoTerry J Smith

Abstract

Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator protein (AIRE). Fibrocytes respond robustly to TSH and thyroid-stimulating Igs by generating extremely high levels of inflammatory cytokines, such as IL-6. In TAO, they appear to infiltrate the orbit, where they transition to CD34+ orbital fibroblasts (OF). There, they coexist with CD34- OF as a mixed fibroblast population (GD-OF). In contrast to fibrocytes, GD-OF express vanishingly low levels of MHC-2, Tg, TSHR, and AIRE. Further, the amplitude of IL-6 induction by TSH in GD-OF is substantially lower. The molecular basis for this divergence between fibrocytes and CD34+ OF remains uncertain. In this article, we report that Slit2, an axon guidance glycoprotein, is constitutively expressed by the CD34- OF subset of GD-OF. Culture conditioned medium (CM) generated by incubating with GD-OF and CD34- OF substantially reduces le...Continue Reading

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Citations

Nov 18, 2018·The Journal of Clinical Endocrinology and Metabolism·Terry J Smith
Sep 15, 2018·Endocrine Reviews·Terry J Smith, Joseph A M J L Janssen
Feb 11, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Terry J Smith
Feb 23, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roshini FernandoTerry J Smith
Sep 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Roshini Fernando, Terry J Smith
Apr 20, 2021·Frontiers in Endocrinology·Sijie FangXianqun Fan
Jun 14, 2021·Korean Journal of Ophthalmology : KJO·Volkan YeterElif Kiliç Kan
Aug 22, 2021·Journal of Endocrinological Investigation·E J Neag, T J Smith
Aug 25, 2021·Inflammatory Bowel Diseases·Aito UenoPaul L Beck

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