Slits and Robos in the developing chicken inner ear.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Andrea C Battisti, Donna M Fekete

Abstract

Mechanosensory hair cells in the chick inner ear synapse onto afferent neurons of the statoacoustic ganglion (SAG). During development, these neurons extend a central process to the brain and a peripheral process into one of eight sensory organs. A combination of cues, including chemoattractants and chemorepellents, direct otic axons to their peripheral targets. As a first step in evaluating the role of known axon guidance molecules, Slits and Robos, we examined expression of their transcripts in the chick inner ear from embryonic day 2-11 (Hamburger and Hamilton stages 14-37). Robo2 and slit2 are in migrating neuroblasts and the SAG, while both slits and robos are in the otic epithelium. We speculate that this family of signaling molecules may be involved in repulsion, first of otic neuroblasts and then of otic axons. Later our expression data revealed a potentially novel role for these molecules in maintaining sensory/nonsensory boundaries.

References

Aug 1, 1989·The Journal of Experimental Zoology·S R HilferJ F Sanzo
Jan 1, 1985·Neuroscience·M C Whitehead, D K Morest
Apr 1, 1983·The American Journal of Anatomy·A D'Amico-Martel, D M Noden
Apr 20, 1983·The Journal of Comparative Neurology·P R Carney, J Silver
Jun 1, 1980·Journal of Neurocytology·R D Ginzberg, N B Gilula
Feb 8, 1994·The Journal of Comparative Neurology·R A Code, C E Carr
Apr 1, 1994·Journal of Morphology·F P FischerG A Manley
May 13, 1996·The Journal of Comparative Neurology·J P Bissonnette, D M Fekete
Feb 19, 2000·Current Opinion in Neurobiology·K Brose, M Tessier-Lavigne
Nov 10, 2000·Developmental Biology·J V BrigandeD M Fekete
Mar 21, 2001·Nature Reviews. Neuroscience·D G Wilkinson
Jul 27, 2001·Mechanisms of Development·N VargessonE Laufer
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G Holmes, L Niswander
Dec 26, 2001·The Journal of Comparative Neurology·Valérie MarillatAlain Chédotal
Jun 8, 2002·Annual Review of Neuroscience·Edwin W Rubel, Bernd Fritzsch
Aug 30, 2002·Current Opinion in Genetics & Development·Kit WongYi Rao
Apr 5, 2003·Annual Review of Neuroscience·Andrea B HuberJean-François Cloutier
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John K Chilton, Sarah Guthrie
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lino TessarolloBernd Fritzsch
Oct 7, 2004·Gene Expression Patterns : GEP·Hortensia Sánchez-CalderónMatías Hidalgo-Sánchez
Jan 26, 2005·The Journal of Comparative Neurology·Shazia A Siddiqui, Karina S Cramer
Oct 29, 2005·PLoS Genetics·Katariina Hannula-JouppiJuha Kere
Mar 22, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Audra Webber, Yael Raz
Apr 25, 2006·Brain Research·Jacqueline K MorrisBernd Fritzsch
May 13, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah PauleyBernd Fritzsch
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Barry J Dickson, Giorgio F Gilestro
Nov 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kersti LilleväliMarjo Salminen
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Le Ma, Marc Tessier-Lavigne
Sep 25, 2007·The International Journal of Developmental Biology·Donna M Fekete, Andrea M Campero
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations

Aug 20, 2011·Journal of the Association for Research in Otolaryngology : JARO·Saku T SinkkonenStefan Heller
Jul 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheng-zhi WangLi I Zhang
Jan 25, 2014·Hearing Research·Andrea C BattistiDonna M Fekete
Feb 2, 2013·Hearing Research·Fuxin Shi, Albert S B Edge
Jan 15, 2011·Progress in Neurobiology·Jessica M Appler, Lisa V Goodrich
Mar 5, 2009·The Journal of Comparative Neurology·Luis Oscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Sep 19, 2012·The Journal of Comparative Neurology·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Dec 2, 2010·The Journal of Comparative Neurology·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marta MagariñosIsabel Varela-Nieto
Mar 21, 2016·Brain Structure & Function·Daniel Olaya-SánchezMatías Hidalgo-Sánchez
Jul 28, 2015·Gene Expression Patterns : GEP·Kristi NguyenJennifer M Jones
Dec 20, 2018·Journal of the Association for Research in Otolaryngology : JARO·Sigmund J LilianKenna D Peusner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.