SLN approach for nose-to-brain delivery of alprazolam

Drug Delivery and Translational Research
Alok Pratap SinghShubhini A Saraf

Abstract

In the present study, alprazolam-loaded solid lipid nanoparticles were prepared and characterized. They were evaluated for their efficiency in nose-to-brain targeting and biodistribution in a suitable animal model after intranasal delivery. Solid lipid nanoparticles may offer an improvement to nose-to-brain drug delivery since they are able to protect the encapsulated drug from biological and/or chemical degradation. The distribution of the drug to different organs was recorded through biodistribution studies in male Wistar rats and gamma scintigraphy imaging in New Zealand rabbits by tagging the formulation with radioactive substance (99m)Tc. The radioactivity count of various organs was taken as a function of the drug concentration. The study reveals that alprazolam can be rapidly transferred to the brain via intranasal route, bypassing the blood-brain barrier and a direct nose-to-brain transfer. The enhanced rate and extent of transport may help in reducing the dose and dosing frequency, thereby providing ease for ambulatory patients.

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Citations

Jun 27, 2013·Pharmaceutical Research·Céline Passeleu-Le BourdonnecSophie Martel
Jan 18, 2018·Expert Opinion on Drug Delivery·Luigi BattagliaShankar Swaminathan
Aug 28, 2019·Current Medicinal Chemistry·Areen AlshweiatIIdikó Csoka
Feb 25, 2020·Current Pharmaceutical Design·Surbhi Sharma, Shweta Dang
Jun 7, 2019·IET Nanobiotechnology·Anupriya AnandDamodharan Narayanasamy
Feb 4, 2021·Assay and Drug Development Technologies·Dinesh PuriMohd Yasir
Sep 15, 2020·Expert Opinion on Drug Delivery·Mihika ShringarpureAbdelwahab Omri
Mar 31, 2021·Assay and Drug Development Technologies·Alok Pratap SinghDinesh Kumar Gupta
Jul 6, 2021·Pharmaceutical Development and Technology·Rosamaria LombardoRosario Pignatello

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