PMID: 9539129Apr 16, 1998Paper

Slob, a novel protein that interacts with the Slowpoke calcium-dependent potassium channel

Neuron
W M SchopperleIrwin B Levitan

Abstract

Slob, a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium channel, was identified with a yeast two-hybrid screen. Slob and dSlo coimmunoprecipitate from Drosophila heads and heterologous host cells, suggesting that they interact in vivo. Slob also coimmunoprecipitates with the Drosophila EAG potassium channel but not with Drosophila Shaker, mouse Slowpoke, or rat Kv1.3. Confocal fluorescence microscopy demonstrates that Slob and dSlo redistribute in cotransfected cells and are colocalized in large intracellular structures. Direct application of Slob to the cytoplasmic face of detached membrane patches containing dSlo channels leads to an increase in channel activity. Slob may represent a new class of multi-functional channel-binding proteins.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·D M EngelmanA Goldman
Jan 1, 1994·Annual Review of Physiology·I B Levitan
May 10, 1995·Annals of the New York Academy of Sciences·S L SwopeR L Huganir
Jan 1, 1995·Annual Review of Biochemistry·W A Catterall
Jan 27, 1995·Cell·G B CohenD Baltimore
Dec 13, 1996·The Journal of Biological Chemistry·C Fuhrer, Z W Hall
Dec 1, 1996·Trends in Biochemical Sciences·J Saras, C H Heldin
Sep 1, 1997·Biophysical Journal·M Schreiber, L Salkoff

❮ Previous
Next ❯

Citations

Jun 15, 2006·The Journal of Membrane Biology·G D HousleyE N Yamoah
May 22, 2003·Progress in Neurobiology·Rae Nishi
Oct 31, 2000·The Journal of General Physiology·N ZilberbergS A Goldstein
Feb 2, 2011·The Journal of General Physiology·Huifang MaIrwin B Levitan
Jan 24, 2004·Journal of Experimental Botany·Isabelle Chérel
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·B GanetzkyS A Titus
Oct 17, 2003·The Journal of Physiology·Hélène A WidmerMichael J Shipston
Jan 21, 2010·Molecular and Cellular Biology·Hiroshi TakeuchiMasato Hirata
Feb 5, 2002·Annual Review of Physiology·Carol Deutsch
Aug 7, 2009·American Journal of Physiology. Renal Physiology·Wen LiuLisa M Satlin
Dec 13, 2005·Journal of Neurophysiology·Angela M JaramilloIrwin B Levitan
Apr 4, 2009·Physiological Reviews·Shuiping DaiJohannes W Hell
Mar 10, 2004·BMC Neuroscience·Angela M JaramilloIrwin B Levitan
May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger RezzonicoHeidy Schmid-Antomarchi
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohammad ShahidullahIrwin B Levitan
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bojun ChenZhao-Wen Wang
Jan 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·F LesageA J Hudspeth
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·N MalloukB Allard
Oct 16, 2013·The Journal of General Physiology·Toshinori HoshiYutao Tian
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James JepsonIrwin B Levitan
Feb 25, 2006·Nature Neuroscience·Irwin B Levitan
Aug 20, 2015·Biomolecules·Anton HermannThomas M Weiger
Oct 22, 2005·The Journal of Physiology·Rong LuLigia Toro
Sep 10, 2005·The Journal of Physiology·Henrike ThurmDominik Oliver
Dec 6, 2005·Biochemical and Biophysical Research Communications·Christian DerstStefan H Heinemann
Dec 26, 2001·Biophysical Journal·Krishnan Ramanathan, Paul A Fuchs
Nov 6, 2004·Neuropharmacology·Zoe A McCrossan, Geoffrey W Abbott
Nov 28, 2012·Journal of Neurogenetics·Roman V FrolovSatpal Singh
Jul 16, 2008·The FEBS Journal·Simon J GunningGraham M Nicholson
Jun 17, 2008·Expert Opinion on Therapeutic Targets·Luis A Pardo, Walter Sühmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.