PMID: 2119805Aug 30, 1990Paper

Slow active/inactive transition of the mitochondrial NADH-ubiquinone reductase

Biochimica Et Biophysica Acta
A B Kotlyar, A D Vinogradov

Abstract

NADH-ubiquinone reductase of bovine heart submitochondrial particles as prepared is unable to catalyze either the direct or reverse electron transfer from NADH to ubiquinone. The deactivated state of the enzyme in coupled particles was revealed as: (i) the absence of the rotenone-sensitive, delta mu H(+)-dependent succinate-ferricyanide reductase activity; (ii) a prominent lag in the aerobic succinate-supported, delta mu H(+)-dependent NAD+ reduction; and (iii) a lag in the rotenone-sensitive NADH-ubiquinone reductase or NADH oxidase activities. Being inactive as NADH-ubiquinone reductase (direct or reverse), the enzyme is fully active as rotenone-insensitive NADH-ferricyanide reductase. The enzyme can be activated by preincubation with substrates (NADH or NADPH) only under the conditions where the turnover of the NADH-ubiquinone reductase reaction (but not in the NADH-ferricyanide reductase) occurs. Partial activation of the enzyme was observed when the particles were preincubated with rotenone. Neither NADH under the conditions when the ubiquinone pool was reduced nor succinate plus delta mu H+ or dithionite were able to activate the enzyme. Once activated, the enzyme remains in the active state for quite a long time (more th...Continue Reading

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Citations

Jun 14, 2008·Archives of Microbiology·Po-Chi LinJulia Steuber
May 21, 2005·Journal of Bioenergetics and Biomembranes·S Tsuyoshi OhnishiKozo Utsumi
Oct 11, 2008·Journal of Bioenergetics and Biomembranes·Anabella F LodeyroOscar A Roveri
May 17, 2005·Journal of Molecular and Cellular Cardiology·Vladimir ShneyvaysAsher Shainberg
Feb 11, 2003·Analytical Biochemistry·Irina S GostimskayaAndrei D Vinogradov
Sep 1, 2007·Biochemistry·Vera G GrivennikovaAndrei D Vinogradov
Aug 16, 2002·European Journal of Biochemistry·Alexander B Kotlyar, Natalia Borovok
Oct 29, 2009·The Journal of Biological Chemistry·Alexander GalkinSalvador Moncada
Feb 20, 2013·Antioxidants & Redox Signaling·Natalia GorenkovaAlexander Galkin
Jun 15, 1994·European Journal of Biochemistry·A M De Jong, S P Albracht
Feb 5, 2014·Biochemistry. Biokhimii︠a︡·V G Grivennikova, A D Vinogradov
Feb 25, 2014·Biochimica Et Biophysica Acta·Stefan DröseIlka Wittig
Mar 27, 2013·Annual Review of Biochemistry·Judy Hirst
Dec 23, 1998·FEBS Letters·I P KrasinskayaL S Yaguzhinsky
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Aug 19, 2005·FEBS Letters·Alexander B KotlyarGary Cecchini
Mar 5, 2013·FEBS Letters·Margherita CianoAlexander Galkin
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Dec 3, 2015·Biochimica Et Biophysica Acta·Masatoshi Murai, Hideto Miyoshi
Feb 28, 2016·Biochimica Et Biophysica Acta·Christophe WirthVolker Zickermann
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Nov 17, 2015·Biochimica Et Biophysica Acta·Andrei D Vinogradov, Vera G Grivennikova
May 27, 2015·Biochimica Et Biophysica Acta·Anna StepanovaAlexander Galkin
Jun 1, 1995·Biochimica Et Biophysica Acta·E V GavrikovaA D Vinogradov
Jul 12, 2005·Journal of Molecular Biology·Alexandra V UshakovaArnaldo Videira

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