PMID: 8592192Nov 1, 1995Paper

Slow and fast synaptic inhibition evoked by pattern-generating neurons of the gastric mill network in spiny lobsters

Journal of Neurophysiology
R C Elson, A I Selverston

Abstract

1. In this paper we begin an assessment of the role of synaptic properties, especially synaptic time course, in the function of the central pattern generator circuit (CPG) that controls rhythmic movements of the gastric mill in the foregut of spiny lobster (Panulirus interruptus). 2. The majority of neurons in the gastric CPG are motor neurons (MNs) that innervate striated muscles of the gastric mill but that also make electrical and inhibitory chemical interconnections within the neuropil of the stomatogastric ganglion. We studied the ionic dependence, pharmacology, and time course of inhibitory postsynaptic potentials (IPSPs) evoked by two such MNs, the dorsal gastric (DG) and lateral gastric (LG), in their central synaptic partners. In the periphery, LG and DG are thought to release glutamate. 3. LG and DG evoke two types of IPSPs in follower neurons. The first, fast type of IPSP rises rapidly (the graded component within 100-300 ms, the spike-mediated components within a few tens of ms), is mediated by increased chloride and potassium conductances, and is blocked by < or = 10 microM picrotoxin (PTX). These fast IPSPs closely resemble the glutamatergic IPSPs described in the pyloric circuit of the same ganglion. 4. The secon...Continue Reading

Citations

Jun 26, 1998·Journal of Neurophysiology·T A Cleland, A I Selverston
Sep 3, 2002·Journal of Neurophysiology·Robert C ElsonMikhail I Rabinovich
Jul 30, 2005·Cellular and Molecular Neurobiology·Allen I Selverston
Aug 17, 2005·The European Journal of Neuroscience·Izabela Panek, Päivi H Torkkeli
Oct 1, 1996·Molecular Neurobiology·T A Cleland
Apr 8, 1998·Annual Review of Neuroscience·E Marder
Dec 8, 2006·Biological cybernetics·Allen I Selverston, Joseph Ayers
Dec 1, 1996·Current Opinion in Neurobiology·E C Cropper, K R Weiss

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