Slow biliary elimination of methyl mercury in the marine elasmobranchs, Raja erinacea and Squalus acanthias

Toxicology and Applied Pharmacology
N Ballatori, J L Boyer

Abstract

The present study examined the ability of two marine elasmobranchs (Raja erinacea, little skate, and Squalus acanthias, spiny dogfish shark) to excrete methyl mercury into bile, a major excretory route in mammals. 203Hg-labeled methyl mercury chloride was administered via the caudal vein, and bile collected through exteriorized cannulas in the free swimming fish. Skates and dogfish sharks excreted only a small fraction of the 203Hg into bile over a 3-day period: in the skate, the 3-day cumulative excretion (as a % of dose) was 0.44 +/- 0.10 (n = 4, +/- SD), 0.71 +/- 0.23 (n = 6), and 1.00 +/- 0.34(n = 4) for doses of 1, 5, and 20 mumol/kg, respectively, while the shark excreted only 0.15 +/- 0.15% (n = 8) at a dose of 5 mumol/kg. As in mammals, the availability of hepatic and biliary glutathione was a determinant of the biliary excretion of methyl mercury in these species: the administration of sulfobromophthalein, a compound known to inhibit both glutathione and methyl mercury excretion in rats, or of L-buthionine-S,R-sulfoximine, an inhibitor of glutathione biosynthesis, decreased the biliary excretion of both glutathione and mercury in the skate. The slow hepatic excretory process for methyl mercury in the skate and shark wa...Continue Reading

References

Apr 1, 1976·The American Journal of Physiology·J L BoyerN Smith
Jan 1, 1975·Acta Pharmacologica Et Toxicologica·T Refsvik, T Norseth
Apr 1, 1976·The American Journal of Physiology·J L BoyerN Smith
Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·N Ballatori, T W Clarkson
Aug 16, 1969·Nature·S Jensen, A Jernelöv

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Citations

Apr 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M E BlazkaZ A Shaikh
Jan 1, 1991·Drug Metabolism Reviews·N Ballatori
Dec 31, 1997·The American Journal of Physiology·G FrickerJ L Boyer
Jun 1, 2014·Current Environmental Health Reports·Ebany J Martinez-Finley, Michael Aschner

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