Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.

The Journal of Biological Chemistry
A Zweifach, R S Lewis

Abstract

Feedback regulation of Ca2+ release-activated Ca2+ (CRAC) channels was studied in Jurkat leukemic T lymphocytes using whole cell recording and [Ca2+]i measurement techniques. CRAC channels were activated by passively depleting intracellular Ca2+ stores in the absence of extracellular Ca2+. Under conditions of moderate intracellular Ca2+ buffering, elevating [Ca2+]o to 22 mM initiated an inward current through CRAC channels that declined slowly with a half-time of approximately 30 s. This slow inactivation was evoked by a rise in [Ca2+]i, as it was effectively suppressed by an elevated level of EFTA in the recording pipette that prevented increases in [Ca2+]i. Blockade of Ca2+ uptake into stores by thapsigargin with or without intracellular inositol 1,4,5-trisphosphate reduced the extent of slow inactivation by approximately 50%, indicating that store refilling normally contributes significantly to this process. The store-independent (thapsigargin-insensitive) portion of slow inactivation was largely prevented by the protein phosphatase inhibitor, okadaic acid, and by a structurally related compound, 1-norokadaone, but not by calyculin A nor by cyclosporin A and FK506 at concentrations that fully inhibit calcineurin (protein pho...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A FrumanS J Burakoff
Nov 11, 1990·Cell Calcium·J W Putney
Mar 1, 1990·Trends in Biochemical Sciences·P CohenY Tsukitani
Aug 1, 1990·FEBS Letters·P T CohenD J Mann
Oct 1, 1990·Carcinogenesis·S NishiwakiT Yasumoto
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Feb 1, 1995·The Journal of General Physiology·A Zweifach, R S Lewis
Mar 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·R E HonkanenR E Honkanan
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·P A NegulescuM D Cahalan
Mar 1, 1994·Trends in Pharmacological Sciences·C FasolatoT Pozzan
Jun 1, 1993·The Journal of Physiology·M Hoth, R Penner
Oct 1, 1993·Endocrine Reviews·J W Putney, G S Bird
Jan 28, 1993·Nature·M J Berridge
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Zweifach, R S Lewis

❮ Previous
Next ❯

Citations

Apr 5, 2005·Pflügers Archiv : European journal of physiology·Ariel QuintanaMarkus Hoth
Oct 13, 2006·Pflügers Archiv : European journal of physiology·Sahba FatheraziKenneth T Izutsu
May 23, 2001·Molecular and Cellular Endocrinology·S PerretB J Harvey
Jan 13, 1998·Current Opinion in Biotechnology·M D Cahalan, K G Chandy
Mar 22, 2002·British Journal of Pharmacology·Kuo-Jung LoSheau-Huei Chueh
Jan 19, 2005·British Journal of Pharmacology·Sean M WilsonJoseph R Hume
Jun 25, 2003·The Journal of Biological Chemistry·Khaled Machaca
Jul 3, 2013·The Journal of Cell Biology·Archana JhaShmuel Muallem
May 1, 1996·The Journal of General Physiology·A Zweifach, R S Lewis
Jan 28, 2004·The Journal of General Physiology·Andriy V YerominMichael D Cahalan
Jul 13, 2005·The Journal of General Physiology·Jianmin JiangLixia Yue
Oct 27, 2012·Human Molecular Genetics·Amado Carreras-SuredaRubén Vicente
Mar 24, 2010·Annual Review of Immunology·Patrick G HoganAnjana Rao
Mar 13, 2001·Annual Review of Immunology·R S Lewis
Aug 6, 2010·Journal of Neurophysiology·Merve Tekmen, Evanna Gleason
May 5, 2007·Journal of Cell Science·James W Putney
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshiyuki Shibukawa, Takashi Suzuki
Jun 6, 2009·Critical Reviews in Immunology·Hong-Tao Ma, Michael A Beaven
Jan 1, 2010·Journal of Visualized Experiments : JoVE·Pratima Thakur, Alla F Fomina
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J L HarperJ W Daly
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·B GilloB Minke
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·M HothR S Lewis
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ariel QuintanaMarkus Hoth
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Patrick J ShawStefan Feske
May 5, 1997·The Journal of Cell Biology·M HothR S Lewis
Jun 15, 1997·The Journal of Physiology·B SomasundaramM P Mahaut-Smith
Nov 2, 1999·The Journal of Physiology·M Salathe, R J Bookman
Nov 24, 2007·The Journal of Physiology·Salvador BorgesMartin Wilson
Dec 27, 2015·Biochimica Et Biophysica Acta·Markus Hoth

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.