PMID: 2411848Jul 1, 1985Paper

Slow currents through single sodium channels of the adult rat heart

The Journal of General Physiology
J Patlak, M Ortiz

Abstract

The currents through single Na+ channels from the sarcolemma of ventricular cells dissociated from adult rat hearts were studied using the patch-clamp technique. All patches had several Na+ channels; most had 5-10, while some had up to 50 channels. At 10 degrees C, the conductance of the channel was 9.8 pS. The mean current for sets of many identical pulses inactivated exponentially with a time constant of 1.7 +/- 0.6 ms at -40 mV. Careful examination of the mean currents revealed a small, slow component of inactivation at pulse potentials ranging from -60 to -30 mV. The time constant of the slow component was between 8 and 14 ms. The channels that caused the slow component had the same conductance and reversal potential as the fast Na+ currents and were blocked by tetrodotoxin. The slow currents appear to have been caused by repeated openings of one or more channels. The holding potential influenced the frequency with which such channel reopening occurred. The slow component was prominent during pulses from a holding potential of -100 mV, while it was very small during pulses from -140 mV. Ultraslow currents through the Na+ channel were observed occasionally in patches that had large numbers of channels. They consisted of burs...Continue Reading

Citations

Jan 1, 1990·Pflügers Archiv : European journal of physiology·P M Vassilev
Jul 1, 1994·Pflügers Archiv : European journal of physiology·A FleigM D Rayner
Jul 1, 1990·Pflügers Archiv : European journal of physiology·T KimitsukiA Noma
Jul 1, 1990·Pflügers Archiv : European journal of physiology·N Ogata, H Tatebayashi
Apr 1, 1989·Pflügers Archiv : European journal of physiology·K Chinn, T Narahashi
Jan 1, 1987·Pflügers Archiv : European journal of physiology·E Carmeliet
Dec 1, 1986·Pflügers Archiv : European journal of physiology·B NiliusF Markwardt
Jan 1, 1989·Pflügers Archiv : European journal of physiology·B NiliusE Carmeliet
Jul 1, 1989·Pflügers Archiv : European journal of physiology·I R Josephson, N Sperelakis
Feb 1, 1995·Pflügers Archiv : European journal of physiology·K OnoD A Hanck
Nov 1, 1989·The Journal of Membrane Biology·M KohlhardtU Fröbe
Jan 1, 1991·The Journal of Membrane Biology·J W Herzig, M Kohlhardt
Jun 1, 1991·The Journal of Membrane Biology·I Benz, M Kohlhardt
Mar 1, 1988·The Journal of Membrane Biology·S FujiiR L DeHaan
Dec 1, 1987·Experientia·H A FozzardM F Sheets
May 12, 2007·Pflügers Archiv : European journal of physiology·Weiping WangAntao Luo
Mar 6, 2010·Pflügers Archiv : European journal of physiology·Aurélien ChatelierMohamed Chahine
Apr 1, 1996·Pflügers Archiv : European journal of physiology·Y K JuD A Saint
Oct 31, 2012·Cardiovascular Drugs and Therapy·Alexander Burashnikov, Charles Antzelevitch
Jan 1, 2013·Cardiovascular Drugs and Therapy·Antonio Zaza, Marcella Rocchetti
Jan 22, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nael Hawwa, Venu Menon
Dec 1, 1991·Computers and Biomedical Research, an International Journal·J L HurwitzA O Grant
Sep 1, 1992·Trends in Pharmacological Sciences·A O Grant, D J Wendt
Jul 1, 1987·Biophysical Journal·M F SheetsH A Fozzard
May 16, 1997·Journal of Neuroscience Methods·P C RubenM D Rayner
Dec 18, 2001·Brain Research. Developmental Brain Research·J FernandesP F Costa
Jul 1, 1986·Journal of the American College of Cardiology·H A FozzardM F Sheets
Nov 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ilya A FleidervishMichael J Gutnick
May 1, 1997·The Journal of General Physiology·S KellenbergerT Scheuer
Aug 13, 2003·The Journal of General Physiology·Ging Kuo WangSho-Ya Wang
Feb 1, 1986·The Journal of General Physiology·J B Patlak, M Ortiz
Jan 1, 1989·The Journal of General Physiology·G E Kirsch, A M Brown
Mar 1, 1990·The Journal of General Physiology·B E ScanleyH A Fozzard
Mar 1, 1990·The Journal of General Physiology·D A HanckH A Fozzard
Jun 1, 1990·The Journal of General Physiology·C R FrenchP W Gage
Jun 12, 2013·Cardiovascular Research·John C ShryockLuiz Belardinelli
Nov 1, 1990·Pacing and Clinical Electrophysiology : PACE·A O Grant

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