Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan

Journal of Hepatology
Chi-Ling ChenDing-Shinn Chen

Abstract

Hepatitis B virus (HBV) infection poses a global public health threat. HBV vaccination has proven highly effective in preventing the infection; however, its long-term impact on the general population has not been addressed. We conducted analysis to determine the total and changing burden of chronic HBV infection and evaluate the serological status between vaccinated and unvaccinated in Taiwan. Participants in "The Taiwanese Survey on Prevalence of Hyperglycemia, Hyperlipidemia and Hypertension" in 2002 (n=6602), and 4088 with follow-up survey in 2007 were included. HBsAg (including titers), anti-HBs, anti-HBc, HBeAg, anti-HBe, HBV genotypes and viral loads were assayed. Prevalence and evolving patterns of these seromarkers was compared between vaccinated and unvaccinated cohorts and predictors of persistent HBsAg positivity and negativity were examined. The overall prevalence of chronic HBV infection was 13·7% (95% CI, 12.9% to 14.5%) and about two thirds had past exposure (anti-HBc: 68·46%) in 2002. The vaccinated cohort tended to have lower prevalence of HBsAg and anti-HBc, and a higher proportion of anti-HBs and HBeAg positivity, genotype C and high viral load. The majority (85·42%) were consistently HBsAg negative while 12·...Continue Reading

References

Sep 18, 1996·JAMA : the Journal of the American Medical Association·H L ChenD S Chen
Aug 2, 2000·Journal of Gastroenterology and Hepatology·C J ChenM W Yu
Dec 21, 2000·JAMA : the Journal of the American Medical Association·M H ChangUNKNOWN Taiwan Childhood Hepatoma Study Group
Aug 29, 2006·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lee-Ching HwangChien-Jen Chen
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chia-Ming Chu, Yun-Fan Liaw
Oct 11, 2007·European Journal of Epidemiology·Lee-Ching HwangKuo-Liong Chien
Feb 17, 2009·Lancet·Yun-Fan Liaw, Chia-Ming Chu
Apr 7, 2009·Annals of Epidemiology·R Palmer Beasley
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wan-Hsin WenMei-Hwei Chang
Jul 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ding-Shinn Chen
Jun 7, 2012·Journal of Hepatology·Yen-Hsuan NiDing-Shinn Chen
Feb 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yin-Chu ChienChien-Jen Chen

❮ Previous
Next ❯

Citations

Jul 18, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Lin Lin, Jia-Horng Kao
Dec 15, 2015·Best Practice & Research. Clinical Gastroenterology·Jia-Horng Kao
Apr 17, 2016·Journal of Hepatology·Antonio Bertoletti, Carlo Ferrari
Sep 7, 2016·Journal of Hepatology·Jördis J OttRafael T Mikolajczyk
Jan 18, 2017·Hepatology International·Ming WangQin Ning
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Apr 15, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Daxian WuLanjuan Li
Oct 3, 2018·Expert Review of Gastroenterology & Hepatology·Lucas Zhihong LiuHenry Lik Yuen Chan
May 19, 2019·International Journal of Dermatology·Alice Ya-Yun HuangStephen Chu-Sung Hu
Sep 6, 2017·The Korean Journal of Internal Medicine·Jae-Jun ShimByung-Ho Kim
Oct 31, 2015·Occupational and Environmental Medicine·Ting-Chun LaiHsien-Ho Lin
Jan 23, 2019·The Journal of Infectious Diseases·Kevin S H LiuMan-Fung Yuen
May 21, 2016·Alimentary Pharmacology & Therapeutics·P LamperticoT Berg
Jan 7, 2017·Hepatology International·Chih-Lin Lin, Jia-Horng Kao
Jul 18, 2019·Gastroenterology Research and Practice·Jen-Wei ChouTsung-Wei Chen
Dec 29, 2020·Bulletin du cancer·Fanny Lebossé, Fabien Zoulim
Nov 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yun Jung HurJinyoung Paek
Feb 28, 2021·Hepatology International·Apostolos KoffasS K Sarin
Mar 8, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Juliette BesombesVincent Thibault
May 15, 2021·The Lancet Infectious Diseases·Florian van Bömmel, Thomas Berg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.