PMID: 47424Jan 25, 1975Paper

Slow encephalopathies, inflammatory responses and arachis oil

Lancet
G W OutramH Fraser

Abstract

There is much interest in the possibility that diets rich in some plant oils may be of prophylactic and curative value in certain clinical conditions. This is generally attributed to the immunosuppressive effects of polyunsaturated fatty acids. Arachis (peanut) oil injections can increase the incubation period of experimental scrapie in mice. In the late 1950s several workers showed that arachis and some other oils contained very potent anti-inflammatory components quite apart from the polyunsaturated fatty acids. This suggests that the supposed efficacy of these acids in some clinical situations could be due to trace substances rather than the lipid itself and that the apparent ability of scrapie agents to use the host's lymphoreticular system as a Trojan horse may involve elements of the inflammatory system rather than the B/T cell immune system.

Citations

Jun 5, 1998·Immunology Today·Neil A MabbottM E Bruce
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·R H Kimberlin, C A Walker
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Mark W HeadJanet R Fraser
Jul 1, 1976·Journal of Comparative Pathology·R H Kimberlin, G C Millson
Oct 1, 2009·Physiological Reviews·Adriano Aguzzi, Anna Maria Calella
Jan 18, 2019·Viruses·James A Carroll, Bruce Chesebro
Oct 8, 2020·International Journal of Molecular Sciences·Neil A MabbottDavid S Donaldson

Related Concepts

Anti-Inflammatory Agents
Fatty Acids, Unsaturated
Therapeutic Immunosuppression
Immunosuppressive Agents
Inflammation
Subcutaneous Injections
Lymphatic System
Oils
Arachis
Reticuloendothelial System

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