Slow magic-angle coil spinning: a high-sensitivity and high-resolution NMR strategy for microscopic biological specimens

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Alan WongDimitris Sakellariou

Abstract

High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution (1)H NMR spectroscopic approach using magic-angle coil spinning. We demonstrate its potential for intact tissues by combining a resonant microcoil with a large-volume commercial magic-angle spinning rotor, where the microcoil offers incredible sensitivity and the large-volume magic-angle spinning rotor provides stable slow magic-angle spinning. This approach provides high-resolution spectra with high sensitivity and the preservation of living biologic specimens for an accurate chemical analysis.

References

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Citations

Jan 15, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Christian BonhommeDanielle Laurencin
Feb 28, 2016·Journal of Magnetic Resonance·Frédéric A PerrasMarek Pruski
Aug 3, 2010·Journal of Magnetic Resonance·Alan Wong, Dimitris Sakellariou
Nov 29, 2013·Scientific Reports·Marie RenaultStefano Caldarelli
Aug 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nghia Tuan DuongYusuke Nishiyama
Oct 5, 2010·Magnetic Resonance in Chemistry : MRC·Dimitris SakellariouPhilippe Hardy
Jan 24, 2017·Applied Magnetic Resonance·Joanna KrukJacek Kujawski
Oct 22, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Alan Wong, Dimitris Sakellariou
Dec 25, 2010·Chemical Communications : Chem Comm·Pedro M AguiarDimitris Sakellariou
Jul 24, 2012·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Ondrej NikelDeepak Vashishth

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