'Slow pressor' hypertension from low-dose chronic angiotensin II infusion

Clinical and Experimental Pharmacology & Physiology
A EdgleyW Anderson

Abstract

1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hypertension is due to induced growth in systemic resistance vessel walls by the AngII infusions. 3. We report the results of several studies investigating whether there are also induced structural changes in renal resistance vessels during chronic AngII infusions. We have developed models in Sprague-Dawley rats in which low-dose AngII infusions, either into the renal artery (thus restricting the effects to the kidney) or systemically, result in hypertension. 5. In both models, we have evidence suggesting that chronic AngII infusions have resulted in apparent structurally induced reductions in renal vasculature lumen upstream to the glomerulus. 6. The role of these renal changes in the development of the hypertension remain to be determined.

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Citations

Feb 11, 2004·Progress in Biophysics and Molecular Biology·Matthew C Zimmerman, Robin L Davisson
Sep 22, 2006·Antioxidants & Redox Signaling·David W InfangerRobin L Davisson
Aug 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dexter L LeeWilliam J Welch
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