PMID: 18709007Aug 19, 2008Paper

Slow progression of chronic kidney disease and what it is associated with

Prilozi
N EftimovskaM Polenakovic

Abstract

The risk factors for CKD include diabetes, hypertension, smoking, systemic inflammation, obesity, proteinuria, dislipidaemia and anaemia, as well as gender, age, ethnic minority status and positive family history. By screening and adequate treatment of modifiable risk factors we are able to prevent or delay the progression of the disease. The aim of the study was to assess the risk factors associated with rapid progression of CKD and to see what factors are protective of slow progression. The study is retrospective. The medical charts of 116 patients with CKD who had been followed up for several years at the Outpatient Department of the Nephrology Clinic in Skopje were analysed. Patient age ranged from 19 to 78 years. The patients were divided into two groups: fast progressors - group I (n = 82; GFR decline > 0.1 ml/min/month) and slow progressors - group II (n = 34; GFR decline = or < 0.1 ml/min/month) with an average follow-up time of 55 months. Patients with diabetic nephropathy were excluded from the study because they are known to be fast progressors. The following variables were analysed: underlying cause of CKD, gender, age, time of follow-up, initial GFR (calculated creatinine clearance according to the Cockroft and Gau...Continue Reading

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