PMID: 43080Jan 1, 1979

Slow-reacting substance of anaphylaxis: studies on purification and characterisation

Agents and Actions. Supplements
H R MorrisJ R Tippins

Abstract

We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.

Citations

Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin

Jul 1, 1982·Clinical and Experimental Dermatology·R D Camp

Stimulation of arachidonic acid metabolism and generation of thromboxane A2 by leukotrienes B4, C4 and D4 in guinea-pig lung in vitro

Oct 1, 1982·British Journal of Pharmacology·P J Piper, M N Samhoun

Detection of sputum eicosanoids in cystic fibrosis and in normal saliva by bioassay and radioimmunoassay

Jan 1, 1987·British Journal of Clinical Pharmacology·J T ZakrzewskiJ F Costello

Leukotriene B4: a mediator of vascular permeability

Mar 1, 1981·British Journal of Pharmacology·M A BrayM J Smith

Slow-reacting substances and their formation by a lipoxygenase pathway

Dec 1, 1980·Agents and Actions·P J PiperG W Taylor

Related Concepts

Eicosatetraenoic Acids
Lobar Bronchus Structure
Saturated Fat
Cavia porcellus
Ileum
Osmosin
Lipoxygenase-2
Inotropism
Autacoids
Trachea

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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