PMID: 6111025Mar 26, 1981Paper

Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro

Nature
C J HannaR R Schellenberg

Abstract

During a type I allergic reaction histamine, slow-reacting substance of anaphylaxis (SRS-A) and other mediator substances are elaborated from specific tissue sites. In allergic asthma these sites are in the lung and the mediator substances cause airway obstruction by contracting smooth muscle and altering mucociliary function. Unlike histamine, slow-reacting substances (SRSs) have been assessed very little for their roles in obstructive airways disease. This has been partly due to the fact that their chemical nature was unknown until recently and thus pure samples were not available for pharmacological studies. However, SRSs isolated from both immunological and non-immunological reactions have been identified as a combination of two related lipid substances--leukotriene C4 (LTC) and leukotriene D4 (LTD); thus it is now possible to use pure SRSs (leukotrienes) in pharmacological studies of airway smooth muscle. LTC and LTD have been shown to contract guinea pig tracheal and lung parenchymal strips but there is no evidence that these substances produce similar effects on human lung tissue. To clarify this, in vivo pharmacological studies were done to determine the actions of LTC and LTD on smooth muscle strips of human bronchus, ...Continue Reading

References

Oct 1, 1978·The American Review of Respiratory Disease·R J MezeyA Wanner
Sep 1, 1972·The Journal of Experimental Medicine·M KalinerK F Austen
Aug 1, 1971·Acta Physiologica Scandinavica·A A Mathé, K Strandberg
Apr 29, 1980·Biochemical and Biophysical Research Communications·M K BachB Samuelsson
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R A LewisE J Corey
Dec 4, 1980·Nature·S E DahlénB Samuelsson

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Citations

Aug 14, 1998·Journal of Clinical Pharmacology·S C Lazarus
Nov 1, 1989·Agents and Actions·G W CarnathanR G Van Inwegen
Oct 1, 1984·Agents and Actions·A G StewartM R Fennessy
Dec 1, 1981·Agents and Actions·M C HolroydeE V Elliott
Aug 7, 1999·Clinical Reviews in Allergy & Immunology·S E Dahlén
Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·C Y LuS B Yu
Jan 1, 1986·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S R Li, D X Wang
Jan 1, 1997·International Journal of Clinical & Laboratory Research·C VigoritoG Marone
Dec 17, 1981·European Journal of Pharmacology·J M HandC K Buckner
Aug 27, 1982·European Journal of Pharmacology·C L ArmourR R Schellenberg
Jun 1, 1984·European Journal of Pharmacology·B M Weichman, S S Tucker
Jul 13, 1984·European Journal of Pharmacology·B R CreeseW M Bothwell
Feb 26, 1985·European Journal of Pharmacology·S MongS T Crooke
Jun 26, 1987·European Journal of Pharmacology·D W Snyder, P R Bernstein
Jun 20, 1989·European Journal of Pharmacology·C L ArmourJ L Black
Nov 3, 1994·European Journal of Pharmacology·S R TudhopeP J Gardiner
Aug 1, 1982·Prostaglandins·B M Weichman, S S Tucker
Aug 1, 1982·Prostaglandins·T JonesJ Rokach
Jan 1, 1983·Prostaglandins·D F WoodwardM A Wasserman
Dec 1, 1983·Prostaglandins·M H Saad, J F Burka
Dec 1, 1983·Prostaglandins·Y AshidaY Maki
May 1, 1984·Prostaglandins·G Feuerstein
Mar 1, 1984·Prostaglandins·R R Schellenberg, A Foster
Jan 1, 1984·Prostaglandins·J StjernschantzM Sears
Apr 1, 1986·Prostaglandins·C S SpadaA L Nieves
Jun 1, 1988·Prostaglandins·D W Snyder, P R Bernstein
Jan 1, 1989·Pharmacology & Therapeutics·P J Gardiner
Jan 1, 1990·Pharmacology & Therapeutics·S D Brain, T J Williams
Jun 1, 1983·Prostaglandins, Leukotrienes, and Medicine·B R Creese, M K Bach
Sep 1, 1983·Prostaglandins, Leukotrienes, and Medicine·E B Weiss, P C Mullick

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