Slow sinusoidal tilt movements demonstrate the contribution to orthostatic tolerance of cerebrospinal fluid movement to and from the spinal dural space

Physiological Reports
Wim J StokJohannes J Van Lieshout

Abstract

Standing up elicits a host of cardiovascular changes which all affect the cerebral circulation. Lowered mean arterial blood pressure (ABP) at brain level, change in the cerebral venous outflow path, lowered end-tidal PCO2 (PET CO2 ), and intracranial pressure (ICP) modify cerebral blood flow (CBF). The question we undertook to answer is whether gravity-induced blood pressure (BP) changes are compensated in CBF with the same dynamics as are spontaneous or induced ABP changes in a stable position. Twenty-two healthy subjects (18/4 m/f, 40 ± 8 years) were subjected to 30° and 70° head-up tilt (HUT) and sinusoidal tilts (SinTilt, 0°↨60° around 30° at 2.5-10 tilts/min). Additionally, at those three tilt levels, they performed paced breathing at 6-15 breaths/min to induce larger than spontaneous cardiovascular oscillations. We measured continuous finger BP and cerebral blood flow velocity (CBFv) in the middle cerebral artery by transcranial Doppler to compute transfer functions (TFs) from ABP- to CBFv oscillations. SinTilt induces the largest ABP oscillations at brain level with CBFv gains strikingly lower than for paced breathing or spontaneous variations. This would imply better autoregulation for dynamic gravitational changes. We ...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Dec 1, 1987·British Journal of Haematology·A WallmarkI M Nilsson
Nov 1, 1986·Journal of Neurosurgery·M J Rosner, I B Coley
Jan 1, 1973·Acta Neurologica Scandinavica·J Löfgren, N N Zwetnow
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·R R DiehlP Berlit
May 1, 1995·Stroke; a Journal of Cerebral Circulation·A A BirchG Neil-Dwyer
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·F P TiecksD W Newell
Jul 1, 1996·Journal of Applied Physiology·J C BuckeyC G Blomqvist
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E MichelG Jorch
Jul 14, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·W W Nichols, D G Edwards
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·R L HughsonJ K Shoemaker
Oct 3, 2002·Circulation·Rong ZhangBenjamin D Levine
Feb 7, 2003·Journal of Applied Physiology·Johannes J Van LieshoutNiels H Secher
Jun 7, 2003·Stroke; a Journal of Cerebral Circulation·Rune AaslidDavid W Newell
Jun 19, 2003·Physiological Measurement·R B PaneraiJ F Potter
Aug 6, 2003·Medical Engineering & Physics·R B Panerai
Apr 1, 1959·Physiological Reviews·N A LASSEN
Oct 24, 2003·European Journal of Applied Physiology·Clive M BrownMax J Hilz
Jul 31, 2004·The Journal of Physiology·J GisolfJ M Karemaker
Mar 16, 2007·IEEE Transactions on Bio-medical Engineering·Khalid AmbarkiMarc-Etienne Meyer
Mar 20, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arenda Hea van BeekRené Wmm Jansen
Nov 1, 2008·Journal of Applied Physiology·Jurgen A H R ClaassenRong Zhang
Feb 17, 2009·Journal of Mathematical Biology·Andreas A LinningerRichard Penn
Jul 4, 2009·Journal of Applied Physiology·Rogier V ImminkJohannes J Van Lieshout
Jan 20, 2010·Hypertension·Samuel J E LucasPhilip N Ainslie
Sep 21, 2013·Journal of Applied Physiology·Sara QvarlanderAnders Eklund
Nov 23, 2013·Journal of Applied Physiology·R V ImminkJ J van Lieshout
Mar 29, 2014·F1000prime Reports·Philip N Ainslie, Patrice Brassard
May 6, 2014·Frontiers in Physiology·Anne-Sophie G T BronzwaerJohannes J van Lieshout
Sep 11, 2014·Medical Engineering & Physics·Tianne NumanPhilip N Ainslie
Oct 14, 2014·Acta neurochirurgica·Morten AndresenMarianne Juhler
Jan 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jurgen A H R ClaassenUNKNOWN international Cerebral Autoregulation Research Network (CARNet)
Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J VerbreeMjp van Osch
Jan 17, 2017·The Journal of Physiology·Justin S LawleyBenjamin D Levine
Jun 10, 2017·The Journal of Physiology·Daan L K de JongJurgen A H R Claassen
Dec 6, 2017·The Journal of Physiology·David Simpson, Jurgen Claassen

❮ Previous
Next ❯

Citations

Mar 27, 2019·Physiological Reports·Lonnie G Petersen, Shigehiko Ogoh
Jun 24, 2020·Acta neurochirurgica·Keisuke YoshidaMasahiro Jinzaki

❮ Previous
Next ❯

Methods Mentioned

BETA
ISS

Software Mentioned

SPSS
Matlab
SinTilt

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Applied Physiology
Anne-Sophie G T BronzwaerJohannes J Van Lieshout
Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
J GisolfJ M Karemaker
American Journal of Physiology. Heart and Circulatory Physiology
Rong ZhangBenjamin D Levine
© 2022 Meta ULC. All rights reserved