Slow transport of freely movable cytoskeletal components shown by beading partition of nerve fibers in the cat.

Neuroscience
S OchsJ M Li

Abstract

To account for the transport in nerve fibers of tubulin and neurofilament proteins in slow component a, the Structural Hypothesis holds that these proteins are assembled into microtubules and neurofilaments in the cell bodies and the cytoskeletal organelles then moved down in the fibers as part of an interconnected matrix at a uniform rate of about 1 mm/day. The Unitary Hypothesis, on the other hand, considers these proteins to be carried down within the fibers as soluble components or as freely movable small polymers or subunits turning over locally in the stationary cytoskeleton. To differentiate between the two hypotheses, cat L7 dorsal roots were taken at times from 7 to 25 days after their L7 dorsal root ganglia were injected with [3H]leucine to assess the labeling of the cytoskeleton by the use of beading and autoradiography. Beading was induced by a mild stretch and after fast-freezing and freeze-substitution of the roots for histological preparation, the beads were seen in the fibers as a series of expanded regions alternating with constrictions. In the constrictions the cytoskeleton was compacted into an area as small as 5% that of the normal axon, with the axoplasmic fluid and displaceable (freely movable) components ...Continue Reading

References

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Citations

Jan 1, 1992·Cell Motility and the Cytoskeleton·R A Nixon, T B Shea
Sep 1, 1991·Journal of Neuroscience Research·T Tashiro, Y Komiya
Jun 1, 1991·Neurochemical Research·J J Bray, R G Mills
Jun 1, 1991·Journal of Neurocytology·A Reles, R L Friede
Jan 1, 1991·Medical Hypotheses·K J Pienta, D S Coffey
Jun 1, 1992·Journal of Neurochemistry·J J BrayD Bray
Jul 1, 1994·Neurochemical Research·H EndoM I Sabri

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