PMID: 9661971Jul 14, 1998Paper

Slowly progressive cystic leukoencephalopathy with megalencephaly in a Japanese boy

Brain & Development
T Koeda, K Takeshita

Abstract

A Japanese boy with megalencephaly and leukoencephalopathy was reported. The clinical characteristics were as follows; slowly progressive megalencephaly starting at 8 months, and motor impairment with ataxia and spasticity, with relatively preserved intelligence and well-controlled epilepsy, and the following MRI findings; diffuse leukoencephalopathy in the supratentorial white matter with cystic subcortical white matter in the temporal tips and the fronto-parietal lobes. This corresponds to vacuolating leukoencephalopathy with megalencephaly, which was recently reported in European countries. In Japan, there were similar case reports previously, however, the patients were diagnosed as having Alexander's disease. It seems that this new leukoencephalopathy must also be seen among Japanese.

References

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Citations

May 7, 2005·Indian Journal of Pediatrics·B S Singhal
Nov 19, 2003·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Neil Gordon
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shunsuke MeshitsukaHideki Muro
Feb 28, 2001·Brain & Development·C SugiuraK Takeshita
Aug 14, 2003·Seizure : the Journal of the British Epilepsy Association·Cengiz YalçinkayaAyşin Dervent
Nov 4, 2000·Journal of Child Neurology·C YalçinkayaA Ocal
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·J Rafael Gorospe, Jelena Maletkovic
Oct 24, 2003·Journal of Child Neurology·Bhim S SinghalSakkubai Naidu

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