Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial

The Journal of Clinical Psychiatry
Tanya E FroehlichJeffery N Epstein

Abstract

To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects. Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate. ADHD diagnosis and subtype were established according to DSM-IV criteria using a structured interview and teacher ADHD symptom ratings. SCT symptoms were assessed using a teacher-rated scale with 2 factors (Sluggish/Sleepy and Daydreamy). Primary outcomes included (1) categorization of children as methylphenidate responders, methylphenidate nonresponders, or placebo responders by 2 blinded physicians and (2) parent and teacher ratings of child behavior on the Vanderbilt ADHD Diagnostic Rating Scales while subjects were on treatment with placebo or 1 of 3 methylphenidate dosages (low, medium, high). Increased SCT Sluggish/Sleepy factor scores were associated with being a methy...Continue Reading

Associated Clinical Trials

Citations

May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Stephen P Becker
Mar 11, 2018·European Child & Adolescent Psychiatry·Stephen P Becker, Erik G Willcutt
Mar 17, 2020·Frontiers in Psychiatry·Stéphanie BioulacPatricia Sagaspe
Nov 2, 2019·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·G Leonard Burns, Stephen P Becker
Nov 10, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Stephen P Becker

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