Abstract
The hallmark of classical Hodgkin lymphoma (cHL) is the presence of giant, mostly multinucleated Hodgkin-Reed-Sternberg (HRS) cells. Whereas it has recently been shown that giant HRS cells evolve from small Hodgkin cells by incomplete cytokinesis and re-fusion of tethered sister cells, it remains unsolved why this phenomenon particularly takes place in this lymphoma and what the differences between these cell types of variable sizes are. The aim of the present study was to characterize microdissected small and giant HRS cells by gene expression profiling and to assess differences of clonal growth behavior as well as susceptibility toward cytotoxic intervention between these different cell types to provide more insight into their distinct cellular potential. Applying stringent filter criteria, only two differentially expressed genes between small and giant HRS cells, SHFM1 and LDHB, were identified. With looser filter criteria, 13 genes were identified to be differentially overexpressed in small compared to giant HRS cells. These were mainly related to energy metabolism and protein synthesis, further suggesting that small Hodgkin cells resemble the proliferative compartment of cHL. SHFM1, which is known to be involved in the gen...Continue Reading
References
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·H G DrexlerJ Minowada
Nov 1, 1988·International Journal of Cell Cloning·S R NewcomC Phillips
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·H SteinV Diehl
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·R KüppersM L Hansmann
Jun 22, 1999·Molecular and Cellular Biology·N J MarstonA Ashworth
Jan 12, 2000·The Journal of Pathology·M P JansenH C Schouten
Jun 1, 2000·Leukemia & Lymphoma·J Teruya-FeldsteinE S Jaffe
Feb 7, 2001·Blood·R KüppersK Rajewsky
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak
Sep 18, 2004·Science·Matthew J DanielsAshok R Venkitaraman
Jan 29, 2005·Blood·Christoph RennéAndreas Bräuninger
Dec 12, 2007·Blood·Yue MaAnke van den Berg
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Feb 4, 2009·Blood·Richard J JonesWilliam Matsui
Oct 30, 2009·American Journal of Clinical Pathology·Kung-Chao ChangIh-Jen Su
Apr 2, 2010·Journal of Cell Science·Sergey LekomtsevMark Petronczki
Apr 7, 2010·Leukemia & Lymphoma·Jessica A ShaferAaron E Foster
Aug 26, 2010·Cancer Science·Makoto NakashimaRyouichi Horie
Mar 24, 2012·Cancer Cell·Jeffrey A MageeSean J Morrison
May 21, 2013·International Journal of Cancer. Journal International Du Cancer·Sylvia HartmannMartin-Leo Hansmann
Nov 19, 2013·PloS One·Sylvia HartmannMartin-Leo Hansmann
Dec 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Benjamin RengstlMartin-Leo Hansmann
Jan 9, 2015·Blood·Valérie LajoieHans Knecht
May 2, 2015·PloS One·Ana Xavier de CarvalhoClara Sambade
Citations
Sep 24, 2020·International Journal of Laboratory Hematology·Tariq N Aladily
Aug 29, 2018·Cancers·Fabio ContuSabine Mai
Oct 28, 2019·PloS One·Julia LiebersMartin-Leo Hansmann
Nov 2, 2019·Cancers·Katrin BankovSylvia Hartmann