Small and Bright Lithium-Based Upconverting Nanoparticles

Journal of the American Chemical Society
Ting ChengFiorenzo Vetrone

Abstract

In the context of light-mediated tumor treatment, the application of ultraviolet (UV) radiation can initiate drug release and photodynamic therapy. However, its limited penetration depth in tissues impedes the subcutaneous applicability of such radiation. On the contrary, near-infrared (NIR) light is not energetic enough to initiate secondary photochemical processes, but can pierce tissues at a significantly greater depth. Upconverting nanoparticles (UCNPs) unify the advantages of both extremes of the optical spectrum, they can be excited by NIR irradiation and emit UV light through the process of upconversion, effective NIR-to-UV generation being attained with UCNPs as large as 100 nm. However, in anticipation of biomedical applications, the size of UCNPs must be greatly minimized to favor their cellular internalization; yet straightforward size reduction negatively affects the NIR-to-UV upconversion efficiency. Herein, we propose a two-step strategy to obtain small yet bright lithium-based UCNPs. First, we synthesized UCNPs as small as 5 nm by controlling the relative amount of coordinating ligands, namely oleylamine (OM) and oleic acid (OA). Although these UCNPs were chemically unstable, particle coarsening via an annealing ...Continue Reading

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Citations

Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lili XuChunxia Li
Jun 6, 2019·Nanoscale·A SkripkaF Vetrone
Nov 21, 2019·Chemistry, an Asian Journal·Xian ChenFeng Wang
Aug 20, 2020·Nanoscale·Artiom SkripkaFiorenzo Vetrone
Dec 15, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hongqi ChenLun Wang
Jan 20, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Riccardo MarinAntonio Benayas
Jan 20, 2021·ACS Nano·Erving XimendesRiccardo Marin
Jun 3, 2021·Comprehensive Reviews in Food Science and Food Safety·Yawen RongQuansheng Chen
Jul 27, 2021·Advanced Science·Cheng YuJingzhi Ma
Aug 12, 2021·ACS Applied Materials & Interfaces·Evelina VoronovicVitalijus Karabanovas
May 7, 2019·Nano Letters·Stefan FischerJennifer A Dionne
Jul 31, 2019·ACS Applied Materials & Interfaces·Xiaowang LiuBaoyou Geng
Oct 22, 2019·Accounts of Chemical Research·Bing Chen, Feng Wang
Jan 7, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vaidas KlimkeviciusVitalijus Karabanovas

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