PMID: 1765082Dec 18, 1991Paper

Small and medium-angle X-ray analysis of bacterial lipoteichoic acid phase structure

European Journal of Biochemistry
H LabischinskiW Fischer


X-ray scattering analysis was performed on various types of bacterial lipoteichoic acid in solution. The X-ray data show that all samples investigated were characterized by a similar micellar ultrastructure (hydrophilic moiety on the outside) with a fatty acid chain conformation of the disordered, alpha-type at all temperatures between 5 degrees-53 degrees C. The size distribution of Staphylococcus aureus lipoteichoic acid micelles was sufficiently homogeneous to determine their size and some related molecular parameters by detailed small-angle X-ray scattering analysis. Nearly independent of the degree of D-alanine substitution and the ionic strength of the aqueous dispersion, an average micelle contained about 150 lipoteichoic acid molecules arranged in a spherical assembly with a diameter of about 22 nm, whereby the hydrophilic region occupied an outer shell of about 8.5 nm thickness. Based on the average chain length of lipoteichoic acid, it could be estimated that each glycerophosphate residue contributed by about 0.34 nm to the thickness of the hydrophilic shell as compared to a theoretical value of approximately 0.8 nm for a fully extended chain conformation, indicating a highly coiled conformation of the hydrophilic cha...Continue Reading


Dec 1, 1975·Biochemical and Biophysical Research Communications·R F ClevelandG D Shockman
Mar 28, 1975·Science·A J Wicken, K W Knox
May 31, 1977·Biochimica Et Biophysica Acta·P A LambertJ Baddiley
Jan 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·W FischerG Hagen
Jan 1, 1988·Advances in Microbial Physiology·W Fischer
Jan 15, 1985·European Journal of Biochemistry·T Briese, R Hakenbeck
Dec 1, 1985·Biochemical Society Transactions·W Fischer, H U Koch
Jul 1, 1983·European Journal of Biochemistry·W FischerR Haas
Dec 4, 1984·Biochimica Et Biophysica Acta·H L Casal, H H Mantsch
May 1, 1980·Quarterly Reviews of Biophysics·J N IsraelachviliR G Horn


May 1, 1994·Medical Microbiology and Immunology·W Fischer
Apr 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jörg WeckeW Fischer
Jan 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·W Fischer
Mar 15, 1997·European Journal of Biochemistry·W FischerH Labischinski
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·S al-ObeidL Gutmann
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Hélène Bierne, Pascale Cossart
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·F C Neuhaus, J Baddiley
Jan 22, 2014·International Journal of Medical Microbiology : IJMM·Friedrich GötzThilo Stehle
Nov 27, 1999·Scandinavian Journal of Infectious Diseases·L H VorlandJ S Svendsen
Sep 23, 2016·Pharmaceuticals·Nermina Malanovic, Karl Lohner

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