Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

Journal of Bone Oncology
Camille JacquesDominique Heymann

Abstract

Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients. However, a large number of patients still suffer significant therapy related toxicities or die of refractory and metastatic disease. To better delineate the pathogenesis of bone sarcomas and to identify and test new therapeutic options, major efforts have been invested over the past decades in the development of relevant pre-clinical animal models. Nowadays, in vivo models aspire to mimic all the steps and the clinical features of the human disease as accurately as possible and should ideally be manipulable. Considering these features and given their small size, their conduciveness to experiments, their affordability as well as their human-like bone-mi...Continue Reading

Citations

Oct 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Courtney SakolishIvan Rusyn
Aug 24, 2019·Veterinary and Comparative Oncology·Liliana Endo-MunozNicholas A Saunders
Sep 16, 2019·BMC Cancer·Tanmay M ShekharChristine J Hawkins
Sep 1, 2018·Cancer Metastasis Reviews·Dylan C DeanZhenfeng Duan
Sep 29, 2019·Pharmacological Reviews·Peter J Houghton, Raushan T Kurmasheva
Nov 17, 2019·International Journal of Molecular Sciences·Jana SchneiderMartin S Staege
Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann
Feb 26, 2021·Journal of Toxicologic Pathology·Yasuhiro ShimadaTakashi Yao
May 1, 2021·Journal of Clinical Medicine·Roland ImleAna Banito
Jun 12, 2021·Stem Cell Research & Therapy·Marwa S KhattabMamdouh Afify
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Aug 2, 2019·Ocular Oncology and Pathology·Jenna May KimRenelle Pointdujour-Lim

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Methods Mentioned

BETA
biopsies
Xenografts
xenograft
transgenic

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