Small-animal PET: what is it, and why do we need it?

Journal of Nuclear Medicine Technology
Rutao YaoElpida S Crawford

Abstract

Small-animal PET refers to imaging of animals such as rats and mice using dedicated PET scanners. Small-animal PET has been used extensively in modern biomedical research. It provides a quantitative measure of the 3-dimensional distribution of a radiopharmaceutical administered to a live subject noninvasively. In this article, we will discuss the operational and technical aspects of small-animal PET; make some comparisons between small-animal PET and human PET systems; identify the challenges of, opportunities for, and ultimate limitations in applying small-animal PET; and discuss some representative small-animal PET applications. Education objectives: After reading this article, the technologist will be able to explain the requirements and benefits of small-animal PET in biomedical research, describe the design and general characteristics of a small-animal PET system, list and describe some of the challenges of imaging small animals, and discuss several small-animal PET applications.

Citations

Oct 23, 2013·Molecular Diagnosis & Therapy·Lídia CunhaLuís F Metello
Oct 7, 2015·Trends in Plant Science·Michiel Hubeau, Kathy Steppe
Aug 27, 2014·Nuclear Medicine and Biology·Jonas Grafström, Sharon Stone-Elander
Jan 13, 2015·Neuroscience Research·Chihiro Yokoyama, Hirotaka Onoe
Jun 8, 2015·The Cancer Journal·Scott Keith Lyons
Aug 10, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Boeun LeeJae Min Jeong
Mar 17, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Michael L Nickels, Mark D Pagel
Apr 25, 2017·Neurotoxicology and Teratology·Cheng WangFang Liu
Oct 4, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Julia G MannheimMarc C Huisman
Feb 7, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Thitaphat NgernsutivorakulRobert T Kennedy
Feb 8, 2018·Medical & Biological Engineering & Computing·Stéphanie BricqAlain Lalande
Mar 25, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Seth T GammonMy N Helms
Sep 30, 2015·Physics in Medicine and Biology·Frank P DiFilippo
Jun 7, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kristina HerfertBernd J Pichler
Mar 28, 2019·Frontiers in Medicine·Eric J MeesterMarion de Jong
Sep 16, 2018·Brain, Behavior, and Immunity·Katie N MurrayJoanna C Neill
Apr 12, 2020·Journal of Nuclear Medicine Technology·Ismet Sarikaya
Dec 8, 2019·Journal of Nuclear Medicine Technology·Ismet Sarikaya, Ali Sarikaya
Oct 14, 2020·Current Medical Imaging·Khalid AlzimamiSalem Sassi
Jun 25, 2014·Molecular Pharmaceutics·Jiake HeJashvant D Unadkat
Jan 31, 2018·Molecular Pharmaceutics·Ji-Ae ParkYong Jin Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Michael C KreisslHeinrich R Schelbert
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Changqing LiS R Cherry
Annual Review of Biomedical Engineering
Yuan-Chuan Tai, Richard Laforest
© 2021 Meta ULC. All rights reserved