Small Bowel Transit and Altered Gut Microbiota in Patients With Liver Cirrhosis

Frontiers in Physiology
Yang LiuYunwei Wei

Abstract

Disturbance of the gut microbiota is common in liver cirrhosis (LC) patients, the underlying mechanisms of which are yet to be unfolded. This study aims to explore the relationship between small bowel transit (SBT) and gut microbiota in LC patients. Cross-sectional design was applied with 36 LC patients and 20 healthy controls (HCs). The gut microbiota was characterized by 16S rRNA gene sequencing. The Firmicutes/Bacteroidetes (F/B) ratio and the Microbial Dysbiosis index (MDI) were used to evaluate the severity of microbiota dysbiosis. The scintigraphy method was performed in patients to describe the objective values of SBT. Patients were then subdivided according to the Child-Pugh score (threshold = 5) or SBT value (threshold = 0.6) for microbiota analysis. LC patients were characterized by an altered gut microbiota; F/B ratios and MDI were higher than HC in both Child_5 (14.00 ± 14.69 vs. 2.86 ± 0.99, p < 0.01; 0.49 ± 0.80 vs. -0.47 ± 0.69, p < 0.01) and Child_5+ (15.81 ± 15.11 vs. 2.86±0.99, p < 0.01; 1.11 ± 1.05 vs. -0.47 ± 0.69, p < 0.01) sub-groups in patients. Difference in the gut microbiota between Child_ 5 and Child_5+ patients was inappreciable, but the SBT was relatively slower in Child_5+ patients (43 ± 26% vs. 80...Continue Reading

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Citations

Dec 12, 2019·The Journal of Biological Chemistry·Marie-Christine SimonMichael Roden
Oct 13, 2020·Digestive Diseases and Sciences·Shuo XuJunfeng Zhang
Jan 3, 2021·Gastroenterology·Rohit MehtaniVirendra Singh
Mar 21, 2021·Applied and Environmental Microbiology·Shaodong WeiTine Rask Licht

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Methods Mentioned

BETA
PCR
electrophoresis
PCA

Software Mentioned

FLASH
Quantitative Insights Into Microbial Ecology platform ( QIIME
pMANOVA
SPSS
PICRUSt
Trimmomatic
Greengenes
vegan
R

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