PMID: 8951490Nov 1, 1996Paper

Small cell carcinoma of the liver: a hitherto unreported variant of hepatocellular carcinoma

Histopathology
F ZanconatiA Zidar

Abstract

We report three cases of an unusual primary carcinoma of the liver composed of small cells. The patients were adult males (56 to 89 years) who presented with jaundice, weight loss and abdominal discomfort. Surgery was attempted in one case. Clinical evolution was rapid, with death ensuing between 1 and 5 months after diagnosis. Surgical (1 case) and autopsy (2) tissues were available for review. All three tumours arose in non-cirrhotic livers. They were composed of broad nests of small epithelial cells with little supporting tissue. They were positive for low-molecular weight keratins and alpha-fetoprotein. One case was immunoreactive for erythropoietin antigen. Expression of neuroendocrine markers was focal and erratic. No immunostaining was observed for carcinoembryonic antigen or S-100 protein. In one case ultrastructural investigation disclosed canaliculi surrounded by microvilli and junctional complexes. In the light of these features, it appears that small cell carcinoma represents a rare, but definite variant of hepatocellular carcinoma. Although it does not segregate in a peculiar clinical setting, it should be distinguished from metastatic pulmonary small cell carcinoma as well as from other malignancies featuring smal...Continue Reading

Citations

Aug 12, 2009·Hepatology International·Hiroyasu MorikawaNorifumi Kawada
Dec 10, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A ZimmermannM W Büchler
Dec 7, 2013·World Journal of Gastroenterology : WJG·Jae-Min JoSang-Hoon Han
Aug 14, 1998·Pathology International·M Fukunaga
Jul 27, 2007·Acta Oncologica·Sung Sook LeeYoon-Koo Kang
Feb 3, 2007·Seminars in Oncology·Shellaine R FrazierTimothy S Loy
Aug 28, 2003·Histopathology·N D TheiseY Nakanuma
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark A WalshauserNirmala Bhoopalam
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Baruch BrennerDavid P Kelsen
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Nov 3, 2021·Surgical Case Reports·Yusuke SekiMasahiro Ishimaru

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