Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases

Human Pathology
Gang WangCharles C Guo

Abstract

Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68 years. Most bladder SmCCs were presented at advanced stage, with tumors invading the muscularis propria and beyond (n = 77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (n = 32), UC in situ (n = 26), glandular (n = 14), micropapillary (n = 4), sarcomatoid (n = 4), squamous (n = 3), and plasmacytoid (n = 1) features. Most SmCCs expressed neuroendocrine markers synaptophysin (41/56), chromogranin (26/55), and CD56 (39/41); however, they did not express UC luminal markers CK20 (0/17), GATA3 (1/30), and uroplakin II (1/22). Some SmCCs showed focal expression of CK5/6 (9/25), a marker for the basal molecular subtype. Furthermore, expression of the retinoblastoma 1 (RB1) gene protein was lost in most of the bladder SmCCs (2/23). The patients' survival was significantly associated with cancer stage but did not show a significant difference between mixed and pure SmCCs. Compared with conventional UC at similar stages, SmCC had a worse prognosis only when patien...Continue Reading

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Citations

Jan 24, 2019·Archives of Pathology & Laboratory Medicine·Charles C Guo, Bogdan Czerniak
Dec 20, 2018·Histopathology·Antonio Lopez-BeltranLiang Cheng
Dec 5, 2018·International Journal of Surgical Pathology·Francesca SanguedolceLuigi Cormio
Jul 18, 2020·Curēus·Samia HossainEugene Choi
Apr 23, 2020·Indian Journal of Pathology & Microbiology·B PraveenBiju S Pillai
Dec 29, 2020·Indian Journal of Surgical Oncology·Shashikant SinghAnurag Singla
Apr 20, 2021·European Urology Focus·Chiara LonatiUNKNOWN EAU-YAU Urothelial Cancer Working Party
Jun 3, 2021·The American Journal of Surgical Pathology·Gang WangPeter Black
Oct 2, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul W HarmsAndrzej A Dlugosz
Nov 28, 2021·International Journal of Molecular Sciences·Marta DomènechCarmen Balañà

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