Small cell lung cancer with paraneoplastic lipase production

Southern Medical Journal
Constantin A DasanuDoru T Alexandrescu

Abstract

Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) paraneoplastic endocrine syndromes is possible with SCLC, and paraneoplastic amylase production has also been described with this malignancy. We present here the first patient with an extensive stage SCLC, exhibiting a marked paraneoplastic lipase production and a syndrome of inappropriate antidiuretic hormone (SIADH) secretion. In our patient, the paraneoplastic hyperlipasemia paralleled both the initial SCLC response to chemotherapy and its subsequent clinicoradiological relapse.

References

Oct 23, 1997·Virchows Archiv : an International Journal of Pathology·T TeradaY Nakanuma
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni BenedettiLucio Crinò
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen MayerBalazs Halmos
Oct 21, 2005·Advances in Therapy·Jen-Tsun LinWei-Shu Wang
Apr 10, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Karsten MüssigManfred Wehrmann

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Citations

Feb 19, 2016·BMC Cancer·Andrea Casadei GardiniGiovanni Luca Frassineti

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