PMID: 11930195Apr 4, 2002Paper

Small cell lung cancer with positive anti-Hu antibodies presenting as gastroparesis

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
David N Moskovitz, Kenneth V Robb

Abstract

Lung cancer is the most common cancer in North America. Small cell lung cancer (SCLC) represents 15% to 25% of lung cancers. SCLC commonly relapses, resulting in a 3% to 8% five- year survival rate. The poor prognosis associated with SCLC is partly due to late diagnosis of the disease. Paraneoplastic syndromes can be early manifestations of SCLC. The potential benefit of early diagnosis has prompted investigations into markers of this disease. Some patients may present with predominantly gastrointestinal dysmotility symptoms that have no obvious explanation. Testing for anti-Hu antibodies, as a valuable marker of SCLC, should be considered in the investigation. A case of SCLC with positive anti-Hu antibodies presenting with intestinal pseudo-obstruction is presented. Gastrointestinal dysmotility as a manifestation of paraneoplastic syndrome is reviewed.

Citations

Dec 26, 2013·Case Reports in Gastrointestinal Medicine·J A C M BurgerR J L F Loffeld
Jan 11, 2013·Case Reports in Medicine·Konstantinos N ArgyriouSantosh Enaganti
Sep 18, 2014·Journal of Neuroinflammation·John E GreenleeNoel G Carlson
May 24, 2008·Gastroenterology Clinics of North America·Purna Kashyap, Gianrico Farrugia

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