Small-cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases

Diagnostic Cytopathology
Yusuke EbisuKoji Tsuta

Abstract

Small-cell neuroendocrine carcinoma (NEC) of the endometrium is extremely rare, and demonstrates an aggressive clinical course. Since reports describing its cytological features are scarce, we aimed to retrospectively analyze these features. Patients with a histopathological diagnosis of NEC who underwent preoperative cytological examination, were enrolled in this study. The cytological features including the background, arrangement, and shape of the neoplastic cells, and the nuclear and cytoplasmic features were reviewed; six patients were enrolled. The conventionally stained, directly sampled cytological specimens showed small neoplastic cell clusters in all cases, as well as isolated neoplastic cells and large clusters in 3 and 2 cases, respectively, in inflammatory or necrotic backgrounds. These neoplastic cells had a high nuclear/cytoplasmic ratio, and round to oval nuclei with powdery chromatin, inconspicuous nucleoli, and scant cytoplasm. Nuclear molding was a characteristic finding. An adenocarcinoma component was also present in 3 cases. Initial cytodiagnosis revealed small-cell NEC and adenocarcinoma or suspected adenocarcinoma in 1 and 4 cases, respectively. The one remaining case was found to be negative and was con...Continue Reading

References

Jan 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K H van HoevenM J Suhrland
Aug 5, 2008·Diagnostic Cytopathology·Min Jung KimSeung Yeon Ha
Jul 8, 2009·Diagnostic Cytopathology·Yoshiaki NorimatsuTadao K Kobayashi
May 31, 2014·Gynecologic Oncology·Maria Atienza-AmoresBritta Weigelt
Mar 6, 2016·The American Journal of Surgical Pathology·Cady E PocrnichAnais Malpica
Dec 18, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Tomoko ArimotoKoji Tsuta

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Citations

Sep 17, 2020·Cancer Cytopathology·Amir-Hossein AkbariRajmohan Murali

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