Small cell neuroendocrine carcinoma of the endometrium with pulmonary metastasis: A clinicopathologic study of a case and a brief review of the literature

Annals of Medicine and Surgery
Antonio D'AntonioPio Zeppa

Abstract

Neuroendocrine carcinomas (NEC) of the female genital tract are aggressive and rare tumors that usually involve the cervix and ovary, and are seen rarely in the endometrium in perimenopausal or postmenopausal women. We presented a case of a73 year-old postmenopausal woman with vaginal bleeding and abdominal pain. A subsequent computerized tomography (CT) scan of pelvis showed an enlarged uterus (20,0 × 12,0 cm) with para-aortic and pelvic lymph node metastases. She underwent surgical debulking and staging of an endometrial tumor with omental metastasis and positive lymph nodes. The pathological diagnosis was primary small cell carcinoma (SCC) combined with endometrioid carcinoma of uterine corpus. Her final FIGO stage was IVB. Three months after surgery CT-total body showed a metastasis to left lung of SCC. Because the small-cell component of endometrial tumor showed a strong positivity for TTF1 as pulmonary counterpart a differential diagnosis with a primary small cell carcinoma of the lung should be made. Identifying an appropriate therapeutic management for SCC of endometrium is challenging since these are extremely rare tumors. An optimal initial therapeutic approach to this rare disease, especially at an advanced stage, ha...Continue Reading

References

Feb 1, 1997·The Journal of Obstetrics and Gynaecology Research·H TsujiokaK Shirakawa
Jun 16, 2004·Archives of Gynecology and Obstetrics·Edgar PetruG Breitenecker
Sep 14, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A KatahiraN Yaegashi
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TsunodaH Kuramoto
May 10, 2006·Histopathology·A D GrahamD M Salter
Sep 18, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·O BigeU Saygili
Dec 7, 2007·The American Journal of Surgical Pathology·Koushan SiamiMichael T Deavers
Jun 27, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jorge Albores-SaavedraEduardo Luevano
Jun 29, 2010·American Journal of Obstetrics and Gynecology·Joshua G CohenJohn K Chan

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Citations

Jul 25, 2017·Current Oncology Reports·Brooke E HowittW Glenn McCluggage
Aug 11, 2020·The American Journal of Surgical Pathology·Brooke E HowittW Glenn McCluggage

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Methods Mentioned

BETA
biopsy
hysterectomy

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