PMID: 15381906Sep 24, 2004Paper

Small cell neuroendocrine carcinomas of the uterine cervix: a histological, immunohistochemical, and molecular genetic study

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Gabriela Mirei IshidaTeiichi Motoyama

Abstract

Small cell carcinomas of the uterine cervix are rare tumors with an aggressive behavior. Although these tumors can exhibit neuroendocrine differentiation, the criteria for neuroendocrine differentiation are subjective and not well defined. In this study, the authors tentatively defined small cell neuroendocrine carcinoma (SCNEC) as a tumor composed of small cells with at least two of the following: argyrophilic cytoplasm, chromogranin A immunoreactivity, and synaptophysin immunoreactivity. We found 10 cases fulfilling these requirements. Five of the 10 tumors were composed mainly of small ("oat") cells and 5 of mainly larger "intermediate" cells. The majority of both subtypes showed an insular pattern. Three of the 10 SCNECs were pure, whereas the other seven were mixed with adenocarcinoma and/or squamous cell carcinoma or cervical intraepithelial neoplasia. In addition to the definitional markers noted earlier, the tumors were immunoreactive for serotonin (6 cases), somatostatin, gastrin, glucagon, and pancreatic polypeptide. No tumors were immunoreactive for cytokeratin 20. Human papillomavirus (HPV)-18 was detected in all of the pure tumors and both the SCNEC and adenocarcinomatous components in four of the mixed tumors. No ...Continue Reading

References

May 1, 1991·Japanese Journal of Cancer Research : Gann·H YoshikawaA Iwamoto
Jan 1, 1991·The American Journal of Surgical Pathology·M H StolerA N Walker
Jun 2, 1989·JAMA : the Journal of the American Medical Association·S E KernS R Hamilton
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
Jul 1, 1980·The American Journal of Medicine·M A LojekR K Oldham
Aug 1, 1997·The American Journal of Surgical Pathology·C B GilksP B Clement
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R Salgia, A T Skarin
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M CroceK Huebner
Sep 2, 1999·The New England Journal of Medicine·M J SecklJ R Seckl
May 9, 2001·The American Journal of Surgical Pathology·A MaitraJ Albores-Saavedra
Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A Chavez-BlancoA Dueñas-Gonzalez
Dec 13, 2002·Annals of Diagnostic Pathology·Michael G ConnerJorge Albores-Saavedra
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Yuichiro SatoTohru Hayashi
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Zhe JinTeiichi Motoyama

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Citations

May 26, 2005·Der Pathologe·D SchmidtF Kommoss
Jun 15, 2012·Archives of Gynecology and Obstetrics·Peng PengShen Keng
Nov 11, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jie LiuHuiping Zhang
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lars-Christian HornCornelia Leo
Jul 1, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Frank MelgozaJoanne Rutgers
Jul 25, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sharon Nofech-MozesZeina Ghorab
Oct 8, 2009·The American Journal of Surgical Pathology·Eric J DuncavageJohn D Pfeifer
Jun 27, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jorge Albores-SaavedraEduardo Luevano
Dec 28, 2012·The Tohoku Journal of Experimental Medicine·Hideki TokunagaNobuo Yaegashi
May 28, 2014·Seminars in Diagnostic Pathology·Elizabeth Euscher, Anais Malpica
May 31, 2014·Gynecologic Oncology·Maria Atienza-AmoresBritta Weigelt
Aug 8, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G ScutieroP Greco
Aug 30, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sumalee SiriaunkgulSurapan Khunamornpong
Mar 1, 2011·Surgical Pathology Clinics·Kay J Park
Mar 28, 2009·Regulatory Peptides·Luigi M PavoneNorma Staiano
Nov 18, 2008·The Journal of Obstetrics and Gynaecology Research·Mahiru KamiyaChiaki Ban
Nov 9, 2012·Histopathology·W Glenn McCluggage
May 6, 2015·Experimental Hematology & Oncology·Xiaoyong ZhengMinghao Zhong
Feb 27, 2016·Journal of Clinical Pathology·Elia GuadagnoMarialaura Del Basso De Caro
Mar 6, 2018·The American Journal of Surgical Pathology·Deyin XingBrigitte M Ronnett
Dec 3, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Robert E EmersonLiang Cheng
May 8, 2018·BMC Cancer·Clemens B TempferGünther A Rezniczek
Jul 25, 2017·Current Oncology Reports·Brooke E HowittW Glenn McCluggage
Jul 29, 2016·Current Opinion in Oncology·Nicholas S Reed
May 3, 2021·Critical Reviews in Oncology/hematology·Giuseppe CarusoInnocenza Palaia
Oct 23, 2020·Archives of Pathology & Laboratory Medicine·Laurie M GriesingerStephanie L Skala

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